(E)-ethyl 4-oxo-4-(2-(5-(2-phenoxyphenyl)picolinoyl)hydrazinyl)but-2-enoate

Base Information

Chemical Name:(E)-ethyl 4-oxo-4-(2-(5-(2-phenoxyphenyl)picolinoyl)hydrazinyl)but-2-enoate
CAS No.:1431771-45-7
Molecular Formula:C₂₄H₂₁N₃O₅
Molecular Weight:431.448
Hs Code.:

Synonyms:(E)-ethyl 4-oxo-4-(2-(5-(2-phenoxyphenyl)picolinoyl)hydrazinyl)but-2-enoate

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Chemical Property of (E)-ethyl 4-oxo-4-(2-(5-(2-phenoxyphenyl)picolinoyl)hydrazinyl)but-2-enoate

Chemical Property:

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Technology Process of (E)-ethyl 4-oxo-4-(2-(5-(2-phenoxyphenyl)picolinoyl)hydrazinyl)but-2-enoate

There total 4 articles about (E)-ethyl 4-oxo-4-(2-(5-(2-phenoxyphenyl)picolinoyl)hydrazinyl)but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1419884-98-2
ethyl perfluorophenyl fumarate

: 1431771-44-6
5-(2-phenoxyphenyl)picolinohydrazide

: 1431771-45-7
(E)-ethyl 4-oxo-4-(2-(5-(2-phenoxyphenyl)picolinoyl)hydrazinyl)but-2-enoate

Guidance literature:: In tetrahydrofuran; ethyl acetate; at 20 ℃;
DOI:10.1021/jm400193d

Reference yield:

: 29682-15-3
methyl 5-bromopicolinate

: 1431771-45-7
(E)-ethyl 4-oxo-4-(2-(5-(2-phenoxyphenyl)picolinoyl)hydrazinyl)but-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / 14 h / Reflux

2: hydrazine hydrate / methanol / 9 h / 65 °C

3: tetrahydrofuran; ethyl acetate / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; hydrazine hydrate; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/jm400193d

Reference yield:

: 1431771-43-5
methyl 5-(2-phenoxyphenyl)picolinate

: 1431771-45-7
(E)-ethyl 4-oxo-4-(2-(5-(2-phenoxyphenyl)picolinoyl)hydrazinyl)but-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 9 h / 65 °C

2: tetrahydrofuran; ethyl acetate / 20 °C

With hydrazine hydrate; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/jm400193d