5-ethyl-N-(2-hydroxy-5-trifluoromethyl-phenyl)-pyrimidine-4-carboxamide

Base Information

Chemical Name:5-ethyl-N-(2-hydroxy-5-trifluoromethyl-phenyl)-pyrimidine-4-carboxamide
CAS No.:1380066-07-8
Molecular Formula:C₁₄H₁₂F₃N₃O₂
Molecular Weight:311.263
Hs Code.:

Synonyms:5-ethyl-N-(2-hydroxy-5-trifluoromethyl-phenyl)-pyrimidine-4-carboxamide

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Chemical Property of 5-ethyl-N-(2-hydroxy-5-trifluoromethyl-phenyl)-pyrimidine-4-carboxamide

Chemical Property:

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Technology Process of 5-ethyl-N-(2-hydroxy-5-trifluoromethyl-phenyl)-pyrimidine-4-carboxamide

There total 5 articles about 5-ethyl-N-(2-hydroxy-5-trifluoromethyl-phenyl)-pyrimidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 454-81-9
2-amino-4-(trifluoromethyl)phenol

: 1355073-93-6
5-ethyl-pyrimidine-4-carboxylic acid

: 1380066-07-8
5-ethyl-N-(2-hydroxy-5-trifluoromethyl-phenyl)-pyrimidine-4-carboxamide

Guidance literature:: With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 80 - 115 ℃; for 3h;

Reference yield:

: 53967-81-0
4,6-dichloro-5-ethylpyrimidine

: 1380066-07-8
5-ethyl-N-(2-hydroxy-5-trifluoromethyl-phenyl)-pyrimidine-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 4 h / 70 - 80 °C

2.1: triethylamine; hydrazine hydrate / tetrahydrofuran / 5 h / Reflux

3.1: pyridine; p-toluenesulfonyl chloride / acetonitrile / 2 h / 20 °C / Cooling with ice

3.2: 3 h / Reflux

4.1: potassium permanganate / water; acetone / 1 h / 50 °C / Reflux

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 3 h / 80 - 115 °C

With pyridine; potassium permanganate; sodium carbonate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; p-toluenesulfonyl chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; acetone; acetonitrile;

Reference yield:

: 1355073-90-3
4-chloro-5-ethyl-6-(furan-2-yl)-pyrimidine

: 1380066-07-8
5-ethyl-N-(2-hydroxy-5-trifluoromethyl-phenyl)-pyrimidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; hydrazine hydrate / tetrahydrofuran / 5 h / Reflux

2.1: pyridine; p-toluenesulfonyl chloride / acetonitrile / 2 h / 20 °C / Cooling with ice

2.2: 3 h / Reflux

3.1: potassium permanganate / water; acetone / 1 h / 50 °C / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 3 h / 80 - 115 °C

With pyridine; potassium permanganate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; water; acetone; acetonitrile;