tert-butyl (4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)methylcarbamate

Base Information

Chemical Name:tert-butyl (4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)methylcarbamate
CAS No.:915296-95-6
Molecular Formula:C₂₀H₂₁Cl₂N₃O₃
Molecular Weight:422.311
Hs Code.:

Synonyms:tert-butyl (4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)methylcarbamate

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Chemical Property of tert-butyl (4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)methylcarbamate

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Technology Process of tert-butyl (4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)methylcarbamate

There total 7 articles about tert-butyl (4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 915296-94-5
tert-butyl (6-(4-methoxybenzyl)-4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)methylcarbamate

: 915296-95-6
tert-butyl (4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)methylcarbamate

Guidance literature:: With ammonium cerium (III) nitrate; water; In acetonitrile;

Reference yield:

: 1346242-64-5
C₁₉H₁₅Cl₂NO₃

: 915296-95-6
tert-butyl (4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid / 1.5 h / Reflux

2: nitric acid / 0.5 h / Reflux

3: methanol; lithium borohydride / 15 h / 20 °C

4: methanesulfonyl chloride; triethylamine / dichloromethane / 2 h / 20 °C

5: ammonia / methanol / 0.08 h / 100 °C / Microwave condition

6: sodium hydrogencarbonate / tetrahydrofuran; water / 12 h / 20 °C

7: ammonium cerium (IV) nitrate / water; acetonitrile / 20 °C

With methanol; lithium borohydride; ammonium cerium (IV) nitrate; ammonia; nitric acid; sodium hydrogencarbonate; acetic acid; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmcl.2011.09.074

Reference yield:

: 1346242-65-6
C₂₄H₂₀Cl₂N₂O₄

: 915296-95-6
tert-butyl (4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: methanol; lithium borohydride / 15 h / 20 °C

2: methanesulfonyl chloride; triethylamine / dichloromethane / 2 h / 20 °C

3: ammonia / methanol / 0.08 h / 100 °C / Microwave condition

4: sodium hydrogencarbonate / tetrahydrofuran; water / 12 h / 20 °C

5: ammonium cerium (IV) nitrate / water; acetonitrile / 20 °C

With methanol; lithium borohydride; ammonium cerium (IV) nitrate; ammonia; sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmcl.2011.09.074