(R)-2-[(S)-2-((S)-2-Acetylamino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid benzylamide

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Chemical Name:(R)-2-[(S)-2-((S)-2-Acetylamino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid benzylamide
CAS No.:872983-87-4
Molecular Formula:C₄₄H₅₆N₄O₅Si
Molecular Weight:749.038
Hs Code.:

Synonyms:(R)-2-[(S)-2-((S)-2-Acetylamino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid benzylamide

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Chemical Property of (R)-2-[(S)-2-((S)-2-Acetylamino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid benzylamide

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Technology Process of (R)-2-[(S)-2-((S)-2-Acetylamino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid benzylamide

There total 6 articles about (R)-2-[(S)-2-((S)-2-Acetylamino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-2-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid benzylamide

: 108-24-7
acetic anhydride

: 872983-87-4
(R)-2-[(S)-2-((S)-2-Acetylamino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid benzylamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1016/j.bmc.2005.08.019

Reference yield:

: 2-amino-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl ester

: 872983-87-4
(R)-2-[(S)-2-((S)-2-Acetylamino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid benzylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / 1-hydroxy-1H-benzotriazole; 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide HCl; triethylamine / CH₂Cl₂ / 0 °C

2: 85 percent / LiOH / tetrahydrofuran; H₂O / 0 °C

3: 57 percent / 1-hydroxy-1H-benzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; triethylamine / CH₂Cl₂ / cooling

4: trifluoroacetic acid / CH₂Cl₂ / 0 °C

5: 0.07 g / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 °C

With dmap; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmc.2005.08.019

Reference yield:

: 872983-86-3
2-[2-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid

: 872983-87-4
(R)-2-[(S)-2-((S)-2-Acetylamino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / 1-hydroxy-1H-benzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; triethylamine / CH₂Cl₂ / cooling

2: trifluoroacetic acid / CH₂Cl₂ / 0 °C

3: 0.07 g / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmc.2005.08.019