(R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-3-fluoro-2-methylbenzonitrile

Base Information

Chemical Name:(R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-3-fluoro-2-methylbenzonitrile
CAS No.:1332652-89-7
Molecular Formula:C₂₁H₂₁FN₂O₂
Molecular Weight:352.408
Hs Code.:

Synonyms:(R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-3-fluoro-2-methylbenzonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-3-fluoro-2-methylbenzonitrile

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Technology Process of (R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-3-fluoro-2-methylbenzonitrile

There total 6 articles about (R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-3-fluoro-2-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 847502-83-4
3,4-difluoro-2-methylbenzonitrile

: 1227380-63-3
(R)-1-benzyl-3-hydroxy-4,4-dimethylpyrrolidin-2-one

: 1332652-89-7
(R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-3-fluoro-2-methylbenzonitrile

Guidance literature:: With caesium carbonate; In acetonitrile; at 20 ℃; for 8h;
DOI:10.1016/j.tetlet.2011.07.021

Reference yield:

: 1332652-82-0
(2R)-2-benzyloxy-4-hydroxy-N-methoxy-N,3,3-trimethylbutanamide

: 1332652-89-7
(R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-3-fluoro-2-methylbenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / 0.83 h / -78 °C

1.2: 16 h / -78 - 20 °C

2.1: sodium tetrahydroborate / methanol

3.1: palladium on activated charcoal; hydrogen

4.1: caesium carbonate / acetonitrile / 8 h / 20 °C

With sodium tetrahydroborate; oxalyl dichloride; palladium on activated charcoal; hydrogen; caesium carbonate; dimethyl sulfoxide; In methanol; acetonitrile; 1.1: Swern oxidation / 1.2: Swern oxidation;
DOI:10.1016/j.tetlet.2011.07.021

Reference yield:

: 1351413-93-8
C₁₅H₂₁NO₄

: 1332652-89-7
(R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-3-fluoro-2-methylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol

2: palladium on activated charcoal; hydrogen

3: caesium carbonate / acetonitrile / 8 h / 20 °C

With sodium tetrahydroborate; palladium on activated charcoal; hydrogen; caesium carbonate; In methanol; acetonitrile;
DOI:10.1016/j.tetlet.2011.07.021