Technology Process of β-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-acrylonitrile
There total 8 articles about β-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-acrylonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 49.7 percent / methanol / 48 h
2: 77 percent / lithium aluminum hydride / diethyl ether / 1.) 0 deg C, 1 h, 2.) 20 deg C, 1 h
3: 87 percent / N-methylmorpholine N-oxide, tris(triphenylphosphine)ruthenium(II) dichloride / acetone / 20 h / Ambient temperature
4: 1.) sodium hydride / 1.) THF, 0 deg C, 40 min, 2.) RT, 2 h
With
lithium aluminium tetrahydride; tris(triphenylphosphine)ruthenium(II) chloride; sodium hydride; 4-methylmorpholine N-oxide;
In
methanol; diethyl ether; acetone;
DOI:10.1021/jm00163a011
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 50 percent / ethanol / 12 h / Heating
2: 1.) NaH / 1a.) toluene, 60 deg C, 30 min, 1b.) 100 deg C, 10 min, 2.) reflux
3: 75 percent / lithium aluminum hydride / tetrahydrofuran / 20 h / Heating
4: 87 percent / N-methylmorpholine N-oxide, tris(triphenylphosphine)ruthenium(II) dichloride / acetone / 20 h / Ambient temperature
5: 1.) sodium hydride / 1.) THF, 0 deg C, 40 min, 2.) RT, 2 h
With
lithium aluminium tetrahydride; tris(triphenylphosphine)ruthenium(II) chloride; sodium hydride; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; ethanol; acetone;
DOI:10.1021/jm00163a011
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 28.9 g / acetic acid / toluene / 16 h / Heating
2: 50 percent / ethanol / 12 h / Heating
3: 1.) NaH / 1a.) toluene, 60 deg C, 30 min, 1b.) 100 deg C, 10 min, 2.) reflux
4: 75 percent / lithium aluminum hydride / tetrahydrofuran / 20 h / Heating
5: 87 percent / N-methylmorpholine N-oxide, tris(triphenylphosphine)ruthenium(II) dichloride / acetone / 20 h / Ambient temperature
6: 1.) sodium hydride / 1.) THF, 0 deg C, 40 min, 2.) RT, 2 h
With
lithium aluminium tetrahydride; tris(triphenylphosphine)ruthenium(II) chloride; sodium hydride; acetic acid; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; ethanol; acetone; toluene;
DOI:10.1021/jm00163a011
