6-chloro-1-(4-fluorophenyl)-3-<1-<2-(N-methylamino)ethyl>-4-piperidinyl>-1H-indole

Base Information

Chemical Name:6-chloro-1-(4-fluorophenyl)-3-<1-<2-(N-methylamino)ethyl>-4-piperidinyl>-1H-indole
CAS No.:139774-10-0
Molecular Formula:C₂₂H₂₅ClFN₃
Molecular Weight:385.912
Hs Code.:

Synonyms:6-chloro-1-(4-fluorophenyl)-3-<1-<2-(N-methylamino)ethyl>-4-piperidinyl>-1H-indole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-chloro-1-(4-fluorophenyl)-3-<1-<2-(N-methylamino)ethyl>-4-piperidinyl>-1H-indole

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Technology Process of 6-chloro-1-(4-fluorophenyl)-3-<1-<2-(N-methylamino)ethyl>-4-piperidinyl>-1H-indole

There total 7 articles about 6-chloro-1-(4-fluorophenyl)-3-<1-<2-(N-methylamino)ethyl>-4-piperidinyl>-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 139773-70-9
ethyl N-<2-<4-<6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl>-1-piperidinyl>ethyl>carbamate

: 139774-10-0
6-chloro-1-(4-fluorophenyl)-3-<1-<2-(N-methylamino)ethyl>-4-piperidinyl>-1H-indole

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 1.5h; Heating;
DOI:10.1021/jm00104a006

Reference yield:

: 40064-34-4
piperidine-4,4-diol hydrochloride

: 139774-10-0
6-chloro-1-(4-fluorophenyl)-3-<1-<2-(N-methylamino)ethyl>-4-piperidinyl>-1H-indole

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid, acetic acid / 0.5 h / Heating

2: H₂ / PtO₂ / ethanol; acetic acid / 20 h / 1520 - 2280 Torr

3: 100 percent / Et₃N / various solvent(s) / 2 h / 60 - 70 °C

4: 76 percent / LiAlH₄, AlCl₃ / diethyl ether; tetrahydrofuran / 1.5 h / Heating

5: 95 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

6: 96 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

With lithium aluminium tetrahydride; aluminium trichloride; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; platinum(IV) oxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00104a006

Reference yield:

: 139774-27-9
6-chloro-1-(4-fluorophenyl)-1H-indole

: 139774-10-0
6-chloro-1-(4-fluorophenyl)-3-<1-<2-(N-methylamino)ethyl>-4-piperidinyl>-1H-indole

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid, acetic acid / 0.5 h / Heating

2: H₂ / PtO₂ / ethanol; acetic acid / 20 h / 1520 - 2280 Torr

3: 100 percent / Et₃N / various solvent(s) / 2 h / 60 - 70 °C

4: 76 percent / LiAlH₄, AlCl₃ / diethyl ether; tetrahydrofuran / 1.5 h / Heating

5: 95 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

6: 96 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

With lithium aluminium tetrahydride; aluminium trichloride; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; platinum(IV) oxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00104a006