2-hydroxy-5-nitrobenzoic acid 2-(1-tricyclo<3.3.1.1>decyl)ethyl ester

Base Information

• Chemical Name: 2-hydroxy-5-nitrobenzoic acid 2-(1-tricyclo<3.3.1.1>decyl)ethyl ester
• CAS No.: 155388-70-8
• Molecular Formula: C₁₉H₂₃NO₅
• Molecular Weight: 345.395
• Mol file: 155388-70-8.mol

Synonyms:2-hydroxy-5-nitrobenzoic acid 2-(1-tricyclo<3.3.1.1>decyl)ethyl ester

Chemical Property of 2-hydroxy-5-nitrobenzoic acid 2-(1-tricyclo<3.3.1.1>decyl)ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxy-5-nitrobenzoic acid 2-(1-tricyclo<3.3.1.1>decyl)ethyl ester

There total 2 articles about 2-hydroxy-5-nitrobenzoic acid 2-(1-tricyclo<3.3.1.1>decyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-nitrosalicylic acid (96-97-9) → 2-hydroxy-5-nitrobenzoic acid 2-(1-tricyclo<3.3.1.1>decyl)ethyl ester (155388-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / toluene / 80 °C

2: 1.) n-BuLi / 1.) THF, hexane, 2.) THF, hexane, RT, 18 h

With n-butyllithium; thionyl chloride; In toluene;

DOI:10.1021/jm00032a020

Reference yield:

2-(adamant-1-yl)ethanol (6240-11-5) + 5-nitrosalicyloyl chloride (3223-20-9) → 2-hydroxy-5-nitrobenzoic acid 2-(1-tricyclo<3.3.1.1>decyl)ethyl ester (155388-70-8)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, 2.) THF, hexane, RT, 18 h;

DOI:10.1021/jm00032a020

Reference yield: 92.0%

2-hydroxy-5-nitrobenzoic acid 2-(1-tricyclo<3.3.1.1>decyl)ethyl ester (155388-70-8) → 5-Amino-2-hydroxy-benzoic acid 2-adamantan-1-yl-ethyl ester (154737-66-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 4h; under 760 Torr;

DOI:10.1021/jm00032a020

upstream raw materials:

2-(adamant-1-yl)ethanol

5-nitrosalicyloyl chloride

5-nitrosalicylic acid

Downstream raw materials:

5-Amino-2-hydroxy-benzoic acid 2-adamantan-1-yl-ethyl ester