1-tert-butyl 2-methyl (2S,4S)-4-((phenylsulfonyl)amino)-1,2-pyrrolidinedicarboxylate

Base Information

Chemical Name:1-tert-butyl 2-methyl (2S,4S)-4-((phenylsulfonyl)amino)-1,2-pyrrolidinedicarboxylate
CAS No.:121148-06-9
Molecular Formula:C₁₇H₂₄N₂O₆S
Molecular Weight:384.453
Hs Code.:

Synonyms:1-tert-butyl 2-methyl (2S,4S)-4-((phenylsulfonyl)amino)-1,2-pyrrolidinedicarboxylate

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Chemical Property of 1-tert-butyl 2-methyl (2S,4S)-4-((phenylsulfonyl)amino)-1,2-pyrrolidinedicarboxylate

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Technology Process of 1-tert-butyl 2-methyl (2S,4S)-4-((phenylsulfonyl)amino)-1,2-pyrrolidinedicarboxylate

There total 7 articles about 1-tert-butyl 2-methyl (2S,4S)-4-((phenylsulfonyl)amino)-1,2-pyrrolidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 121148-06-9
1-tert-butyl 2-methyl (2S,4S)-4-((phenylsulfonyl)amino)-1,2-pyrrolidinedicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 53.4 g / triethylamine / CH₂Cl₂ / 4 h / 0 - 5 °C

2: 56.2 g / triethylamine / CH₂Cl₂ / 3 h / 0 - 5 °C

3: 100 percent / sodium azide / dimethylsulfoxide / 90 °C

4: H₂ / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr

5: 10.55 g / pyridine / 5 h / 0 - 5 °C

With sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In pyridine; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0968-0896(01)00397-2

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 121148-06-9
1-tert-butyl 2-methyl (2S,4S)-4-((phenylsulfonyl)amino)-1,2-pyrrolidinedicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 53.4 g / triethylamine / CH₂Cl₂ / 4 h / 0 - 5 °C

2: 56.2 g / triethylamine / CH₂Cl₂ / 3 h / 0 - 5 °C

3: 100 percent / sodium azide / dimethylsulfoxide / 90 °C

4: H₂ / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr

5: 10.55 g / pyridine / 5 h / 0 - 5 °C

With sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In pyridine; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0968-0896(01)00397-2

Reference yield:

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 121148-06-9
1-tert-butyl 2-methyl (2S,4S)-4-((phenylsulfonyl)amino)-1,2-pyrrolidinedicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 56.2 g / triethylamine / CH₂Cl₂ / 3 h / 0 - 5 °C

2: 100 percent / sodium azide / dimethylsulfoxide / 90 °C

3: H₂ / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr

4: 10.55 g / pyridine / 5 h / 0 - 5 °C

With sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In pyridine; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0968-0896(01)00397-2