3-isopropoxy-phenyl isothiocyanate

Base Information

• Chemical Name: 3-isopropoxy-phenyl isothiocyanate
• CAS No.: 3528-90-3
• Molecular Formula: C₁₀H₁₁NOS
• Molecular Weight: 193.269
• Mol file: 3528-90-3.mol

Synonyms:3-isopropoxy-phenyl isothiocyanate

Chemical Property of 3-isopropoxy-phenyl isothiocyanate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-isopropoxy-phenyl isothiocyanate

There total 1 articles about 3-isopropoxy-phenyl isothiocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

thiophosgene (463-71-8) + 3-isopropoxyaniline (41406-00-2) → 3-isopropoxy-phenyl isothiocyanate (3528-90-3)

Guidance literature:

With calcium carbonate; In dichloromethane; water; at 20 ℃; for 1h;

Reference yield: 72.1%

3-isopropoxy-phenyl isothiocyanate (3528-90-3) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 3-(3-isopropoxy-phenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one (180423-48-7)

Guidance literature:

With acetic acid; for 16h; Heating;

DOI:10.1021/jm970373j

Reference yield:

N-[4-(4-acetylpiperazin-1-yl)phenyl]-2-hydrazino-2-oxoacetamide (892491-46-2) + 3-isopropoxy-phenyl isothiocyanate (3528-90-3) → N-[4-(4-acetylpiperazin-1-yl)phenyl]-5-[(3-isopropoxyphenyl)amino]-1,3,4-oxadiazole-2-carboxamide

Guidance literature:

N-[4-(4-acetylpiperazin-1-yl)phenyl]-2-hydrazino-2-oxoacetamide; 3-isopropoxy-phenyl isothiocyanate; In N,N-dimethyl-formamide; at 85 ℃; for 1h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

upstream raw materials:

thiophosgene

3-isopropoxyaniline

Downstream raw materials:

4-methyl-piperazine-1-carbothioic acid-(3-isopropoxy-anilide)

3-(3-isopropoxy-phenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one

2-amino-3-(3-isopropoxy-phenyl)-3H-quinazolin-4-one

2-hydrazino-3-(3-isopropoxy-phenyl)-3H-quinazolin-4-one

Refernces

• 1、 -. "OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS". Page/Page column 159. . Retrieved 2008/06/13.
• 2、 -. "QUINAZOLINONE DERIVATIVES AS CHOLYECYSTOKININ (CCK) LIGANDS". . . Retrieved 2008/06/13.