(R,S)-S-[4-({5-bromo-4-[(1R,2R)-(2-hydroxy-1-methylpropyl)amino]pyrimidin-2-yl}amino)phenyl]-N-(ethoxycarbonyl)-S-ethylsulfoximide

Base Information

Chemical Name:(R,S)-S-[4-({5-bromo-4-[(1R,2R)-(2-hydroxy-1-methylpropyl)amino]pyrimidin-2-yl}amino)phenyl]-N-(ethoxycarbonyl)-S-ethylsulfoximide
CAS No.:851007-68-6
Molecular Formula:C₁₉H₂₆BrN₅O₄S
Molecular Weight:500.417
Hs Code.:

Synonyms:(R,S)-S-[4-({5-bromo-4-[(1R,2R)-(2-hydroxy-1-methylpropyl)amino]pyrimidin-2-yl}amino)phenyl]-N-(ethoxycarbonyl)-S-ethylsulfoximide

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Chemical Property of (R,S)-S-[4-({5-bromo-4-[(1R,2R)-(2-hydroxy-1-methylpropyl)amino]pyrimidin-2-yl}amino)phenyl]-N-(ethoxycarbonyl)-S-ethylsulfoximide

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Technology Process of (R,S)-S-[4-({5-bromo-4-[(1R,2R)-(2-hydroxy-1-methylpropyl)amino]pyrimidin-2-yl}amino)phenyl]-N-(ethoxycarbonyl)-S-ethylsulfoximide

There total 7 articles about (R,S)-S-[4-({5-bromo-4-[(1R,2R)-(2-hydroxy-1-methylpropyl)amino]pyrimidin-2-yl}amino)phenyl]-N-(ethoxycarbonyl)-S-ethylsulfoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,3R)-3-[(5-bromo-2-chloropyrimidin-4-yl)amino]butan-2-ol

: (R,S)-S-(4-aminophenyl)-N-(ethoxycarbonyl)-S-ethylsulfoximide

: 851007-68-6
(R,S)-S-[4-({5-bromo-4-[(1R,2R)-(2-hydroxy-1-methylpropyl)amino]pyrimidin-2-yl}amino)phenyl]-N-(ethoxycarbonyl)-S-ethylsulfoximide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; acetonitrile; at 20 - 60 ℃; for 24h;
DOI:10.1002/cmdc.201300096

Reference yield:

: 851008-32-7
(R)-2-[(5-bromo-2-chloropyrimidin-4-yl)amino]propanal

: 851007-68-6
(R,S)-S-[4-({5-bromo-4-[(1R,2R)-(2-hydroxy-1-methylpropyl)amino]pyrimidin-2-yl}amino)phenyl]-N-(ethoxycarbonyl)-S-ethylsulfoximide

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 0.67 h / -78 °C / Inert atmosphere

1.2: 6 h / -55 - -35 °C / Inert atmosphere

2.1: hydrogenchloride / acetonitrile; water; 1,4-dioxane / 24 h / 20 - 60 °C

With hydrogenchloride; copper(I) bromide dimethylsulfide complex; In 1,4-dioxane; diethyl ether; water; acetonitrile;
DOI:10.1002/cmdc.201300096

Reference yield:

: 851008-31-6
methyl N-(5-bromo-2-chloropyrimidin-4-yl)-D-alaninate

: 851007-68-6
(R,S)-S-[4-({5-bromo-4-[(1R,2R)-(2-hydroxy-1-methylpropyl)amino]pyrimidin-2-yl}amino)phenyl]-N-(ethoxycarbonyl)-S-ethylsulfoximide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C

2.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 0.67 h / -78 °C / Inert atmosphere

2.2: 6 h / -55 - -35 °C / Inert atmosphere

3.1: hydrogenchloride / acetonitrile; water; 1,4-dioxane / 24 h / 20 - 60 °C

With hydrogenchloride; copper(I) bromide dimethylsulfide complex; diisobutylaluminium hydride; In 1,4-dioxane; diethyl ether; water; toluene; acetonitrile;
DOI:10.1002/cmdc.201300096