{2-(8-allyloxy-1-allyloxymethyl-3-hydroxymethyl-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-oxo-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:{2-(8-allyloxy-1-allyloxymethyl-3-hydroxymethyl-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-oxo-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester
CAS No.:866110-82-9
Molecular Formula:C₅₄H₇₀N₂O₁₁Si
Molecular Weight:951.242
Hs Code.:

{2-(8-allyloxy-1-allyloxymethyl-3-hydroxymethyl-5,7-dimethoxy-6-methyl-3,4-dihydro-1<i>H</i>-isoquinolin-2-yl)-1-[5-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-oxo-ethyl}-methyl-carbamic acid 9<i>H</i>-fluoren-9-ylmethyl ester

Synonyms:{2-(8-allyloxy-1-allyloxymethyl-3-hydroxymethyl-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-oxo-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of {2-(8-allyloxy-1-allyloxymethyl-3-hydroxymethyl-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-oxo-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of {2-(8-allyloxy-1-allyloxymethyl-3-hydroxymethyl-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-oxo-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 15 articles about {2-(8-allyloxy-1-allyloxymethyl-3-hydroxymethyl-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-oxo-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 866110-68-1
C₆₀H₈₄N₂O₁₁Si₂

: 866110-82-9
{2-(8-allyloxy-1-allyloxymethyl-3-hydroxymethyl-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-oxo-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With formic acid; In tetrahydrofuran; at 20 ℃; for 0.75h;
DOI:10.1021/ja0535918

Reference yield:

: (5-benzyloxy-2,4-dimethoxy-3-methyl-phenyl)-methanol

: 866110-82-9
{2-(8-allyloxy-1-allyloxymethyl-3-hydroxymethyl-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-oxo-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: PPh₃; I₂; imidazole / CH₂Cl₂ / 0.5 h / 0 °C

2.1: NaHMDS / tetrahydrofuran / 0.75 h / -78 °C

2.2: 4.73 g / tetrahydrofuran / 4 h / -78 °C

3.1: H₂ / Pd/BaSO₄ / tetrahydrofuran / 24 h / 760 Torr

4.1: trifluoroacetic acid / CH₂Cl₂ / 12 h / 20 °C

5.1: 656 mg / triethylamine; DMAP / CH₂Cl₂ / 24 h / 20 °C

6.1: tetrahydrofuran; acetonitrile; H₂O / 0.25 h / 20 °C

6.2: 72 percent / NaCNBH₃; aq. acetic acid / tetrahydrofuran; acetonitrile / 0.75 h / 20 °C

7.1: H₂ / PdCl₂ / ethanol / 12 h / 760 Torr

8.1: 352 mg / aq. NaHCO₃ / CH₂Cl₂ / 12 h / 20 °C

9.1: oxalyl chloride; DMF / CH₂Cl₂ / 0.33 h / 20 °C

10.1: 109 mg / 2,6-lutidine / CH₂Cl₂ / 0.75 h / 0 °C

11.1: aq. HCO₂H / tetrahydrofuran / 0.75 h / 20 °C

With 1H-imidazole; 2,6-dimethylpyridine; dmap; formic acid; oxalyl dichloride; hydrogen; iodine; sodium hexamethyldisilazane; sodium hydrogencarbonate; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; Pd-BaSO₄; palladium dichloride; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ja0535918

Reference yield:

: 866110-56-7
1-Benzyloxy-5-iodomethyl-2,4-dimethoxy-3-methyl-benzene

: 866110-82-9
{2-(8-allyloxy-1-allyloxymethyl-3-hydroxymethyl-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-oxo-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: NaHMDS / tetrahydrofuran / 0.75 h / -78 °C

1.2: 4.73 g / tetrahydrofuran / 4 h / -78 °C

2.1: H₂ / Pd/BaSO₄ / tetrahydrofuran / 24 h / 760 Torr

3.1: trifluoroacetic acid / CH₂Cl₂ / 12 h / 20 °C

4.1: 656 mg / triethylamine; DMAP / CH₂Cl₂ / 24 h / 20 °C

5.1: tetrahydrofuran; acetonitrile; H₂O / 0.25 h / 20 °C

5.2: 72 percent / NaCNBH₃; aq. acetic acid / tetrahydrofuran; acetonitrile / 0.75 h / 20 °C

6.1: H₂ / PdCl₂ / ethanol / 12 h / 760 Torr

7.1: 352 mg / aq. NaHCO₃ / CH₂Cl₂ / 12 h / 20 °C

8.1: oxalyl chloride; DMF / CH₂Cl₂ / 0.33 h / 20 °C

9.1: 109 mg / 2,6-lutidine / CH₂Cl₂ / 0.75 h / 0 °C

10.1: aq. HCO₂H / tetrahydrofuran / 0.75 h / 20 °C

With 2,6-dimethylpyridine; dmap; formic acid; oxalyl dichloride; hydrogen; sodium hexamethyldisilazane; sodium hydrogencarbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; Pd-BaSO₄; palladium dichloride; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ja0535918