ethyl 3-(2-oxo-1-{4-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]phenyl}-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate

Base Information

Chemical Name:ethyl 3-(2-oxo-1-{4-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]phenyl}-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate
CAS No.:1357196-16-7
Molecular Formula:C₂₉H₂₀F₃N₅O₃
Molecular Weight:543.505
Hs Code.:

Synonyms:ethyl 3-(2-oxo-1-{4-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]phenyl}-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate

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Chemical Property of ethyl 3-(2-oxo-1-{4-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]phenyl}-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate

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Technology Process of ethyl 3-(2-oxo-1-{4-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]phenyl}-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate

There total 7 articles about ethyl 3-(2-oxo-1-{4-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]phenyl}-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15128-82-2
3-hydroxy-2-nitropyridine

: 1357196-16-7
ethyl 3-(2-oxo-1-{4-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]phenyl}-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran / 20 °C

1.2: 72 h / Reflux; oil bath

2.1: potassium phosphate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 24 h / 90 °C

3.1: hydrogen / palladium on activated charcoal / methanol / 20 °C

4.1: triethylamine / tetrahydrofuran / 72 h / 20 °C

5.1: water; lithium hydroxide / water; tetrahydrofuran / 3 h / 20 °C

6.1: sulfuric acid; periodic acid / water; acetic acid / 0.25 h / 90 °C

6.2: 1 h

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 10 - 120 °C / Microwave irradiation

7.2: 0.67 h / 200 °C / Microwave irradiation

8.1: sodium carbonate / N,N-dimethyl-formamide; water / 15 h / 60 °C / Inert atmosphere

With potassium phosphate; sulfuric acid; water; hydrogen; sodium hydride; benzotriazol-1-ol; periodic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; sodium carbonate; In tetrahydrofuran; methanol; water; acetic acid; N,N-dimethyl-formamide; toluene;

Reference yield:

: 146336-72-3
2-nitro-3-(trifluoromethylsulfonyloxy)pyridine

: 1357196-16-7
ethyl 3-(2-oxo-1-{4-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]phenyl}-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium phosphate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 24 h / 90 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 20 °C

3.1: triethylamine / tetrahydrofuran / 72 h / 20 °C

4.1: water; lithium hydroxide / water; tetrahydrofuran / 3 h / 20 °C

5.1: sulfuric acid; periodic acid / water; acetic acid / 0.25 h / 90 °C

5.2: 1 h

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 10 - 120 °C / Microwave irradiation

6.2: 0.67 h / 200 °C / Microwave irradiation

7.1: sodium carbonate / N,N-dimethyl-formamide; water / 15 h / 60 °C / Inert atmosphere

With potassium phosphate; sulfuric acid; water; hydrogen; benzotriazol-1-ol; periodic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; sodium carbonate; In tetrahydrofuran; methanol; water; acetic acid; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1357196-01-0
ethyl 4-(2-oxo-2,3-dihydroimidazo[4,5-b]pyridin-1-yl)benzoate

: 1357196-16-7
ethyl 3-(2-oxo-1-{4-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]phenyl}-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; lithium hydroxide / water; tetrahydrofuran / 3 h / 20 °C

2.1: sulfuric acid; periodic acid / water; acetic acid / 0.25 h / 90 °C

2.2: 1 h

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 10 - 120 °C / Microwave irradiation

3.2: 0.67 h / 200 °C / Microwave irradiation

4.1: sodium carbonate / N,N-dimethyl-formamide; water / 15 h / 60 °C / Inert atmosphere

With sulfuric acid; water; benzotriazol-1-ol; periodic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; sodium carbonate; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide;