4-{[2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl]methyl}-2-fluorobenzonitrile

Base Information

Chemical Name:4-{[2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl]methyl}-2-fluorobenzonitrile
CAS No.:959771-46-1
Molecular Formula:C₂₄H₂₀FN₃O₃
Molecular Weight:417.44
Hs Code.:

Synonyms:4-{[2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl]methyl}-2-fluorobenzonitrile

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Chemical Property of 4-{[2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl]methyl}-2-fluorobenzonitrile

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Technology Process of 4-{[2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl]methyl}-2-fluorobenzonitrile

There total 7 articles about 4-{[2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl]methyl}-2-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959771-45-0
N-[3-(3-cyano-4-fluorophenyl)prop-2-yn-1-yl]-N-(2,4-dimethoxybenzyl)-1H-pyrrole-2-carboxamide

: 959771-46-1
4-{[2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl]methyl}-2-fluorobenzonitrile

Guidance literature:: With tetrabutyl-ammonium chloride; sodium acetate; palladium diacetate; In dimethyl sulfoxide; at 180 ℃; for 0.0833333h; Microwave irradiation;

Reference yield:

: 867338-58-7
N-(2,4-dimethoxybenzyl)prop-2-yn-1-amine

: 959771-46-1
4-{[2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl]methyl}-2-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water; acetonitrile / 12 h / Heating / reflux

2: triethylamine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 20 °C

3: tetrabutyl-ammonium chloride; sodium acetate / palladium diacetate / dimethyl sulfoxide / 0.08 h / 180 °C / Microwave irradiation

With tetrabutyl-ammonium chloride; sodium acetate; sodium hydrogencarbonate; triethylamine; palladium diacetate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 2: Sonogashira Coupling;

Reference yield:

: 351003-36-6
2-fluoro-5-iodobenzonitrile

: 959771-46-1
4-{[2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl]methyl}-2-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 20 °C

2: tetrabutyl-ammonium chloride; sodium acetate / palladium diacetate / dimethyl sulfoxide / 0.08 h / 180 °C / Microwave irradiation

With tetrabutyl-ammonium chloride; sodium acetate; triethylamine; palladium diacetate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Sonogashira Coupling;