2-(((2-Hydroxyphenyl)methylene)amino)benzoic acid

Base Information

• Chemical Name: 2-(((2-Hydroxyphenyl)methylene)amino)benzoic acid
• CAS No.: 7361-93-5
• Molecular Formula: C₁₄H₁₁NO₃
• Molecular Weight: 241.246
• Hs Code.: 2925290090
• European Community (EC) Number: 651-759-5
• NSC Number: 26800
• DSSTox Substance ID: DTXSID901308567
• Nikkaji Number: J1.106.657G,J153.937J
• ChEMBL ID: CHEMBL2260702
• Mol file: 7361-93-5.mol

Synonyms:Salicylideneanthranilic acid;7361-93-5;BRN 2808821;2-(((2-Hydroxyphenyl)methylene)amino)benzoic acid;Benzoic acid, 2-(((2-hydroxyphenyl)methylene)amino)-;4-14-00-01033 (Beilstein Handbook Reference);NSC26800;salicylidene anthranilic acid;CHEMBL2260702;SCHEMBL10812989;2-(salicylideneamino)benzoic acid;DTXSID901308567;NSC 26800;NSC-26800;AKOS024268967;LS-37664;2-[(6-Oxo-2,4-cyclohexadiene-1-ylidene)methylamino]benzoic acid

Chemical Property of 2-(((2-Hydroxyphenyl)methylene)amino)benzoic acid

Chemical Property:

• Vapor Pressure: 7.15E-09mmHg at 25°C
• Boiling Point: 449.7°C at 760 mmHg
• Flash Point: 225.7°C
• PSA: 69.89000
• Density: 1.447g/cm³
• LogP: 2.84100
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 241.07389321
• Heavy Atom Count: 18
• Complexity: 316

Purity/Quality:

2-(SALICYLIDENEAMINO)BENZOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C=NC2=CC=CC=C2C(=O)O)O

Technology Process of 2-(((2-Hydroxyphenyl)methylene)amino)benzoic acid

There total 4 articles about 2-(((2-Hydroxyphenyl)methylene)amino)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

salicylaldehyde (90-02-8) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → salicylaldehyde anthranilic acid (122630-45-9,150063-91-5,7361-93-5)

Guidance literature:

In neat (no solvent, solid phase); at 20 ℃; for 0.333333h;

DOI:10.14233/ajchem.2021.23009

Reference yield: 77.0%

2-methyl-benzyl alcohol (89-95-2) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → salicylaldehyde anthranilic acid (122630-45-9,150063-91-5,7361-93-5)

Guidance literature:

at 20 ℃; for 0.0666667h; microwave irradiation;

DOI:10.1081/SCC-120006012

Reference yield:

salicylic alcohol (90-01-7) → salicylaldehyde anthranilic acid (122630-45-9,150063-91-5,7361-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1: C₂₆H₁₈Mo₂N₂O₆S₂; dihydrogen peroxide / water / 4 h / 70 °C

2: ethanol / 4 h / Reflux

With dihydrogen peroxide; C₂₆H₁₈Mo₂N₂O₆S₂; In ethanol; water;

DOI:10.1002/kin.21530

upstream raw materials:

salicylaldehyde

anthranilic acid

2-methyl-benzyl alcohol

salicylic alcohol