2-(4-(piperidin-1-yl)phenyl)ethyl 5-chloro-3-ethyl-1H-indole-2-carboxylate

Base Information

Chemical Name:2-(4-(piperidin-1-yl)phenyl)ethyl 5-chloro-3-ethyl-1H-indole-2-carboxylate
CAS No.:1377838-00-0
Molecular Formula:C₂₄H₂₇ClN₂O₂
Molecular Weight:410.944
Hs Code.:

Synonyms:2-(4-(piperidin-1-yl)phenyl)ethyl 5-chloro-3-ethyl-1H-indole-2-carboxylate

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Chemical Property of 2-(4-(piperidin-1-yl)phenyl)ethyl 5-chloro-3-ethyl-1H-indole-2-carboxylate

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Technology Process of 2-(4-(piperidin-1-yl)phenyl)ethyl 5-chloro-3-ethyl-1H-indole-2-carboxylate

There total 5 articles about 2-(4-(piperidin-1-yl)phenyl)ethyl 5-chloro-3-ethyl-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 55023-79-5
2-(4-(piperidin-1-yl)phenyl)ethan-1-ol

: 446830-67-7
5-chloro-3-ethyl-1H-indole-2-carboxylic acid

: 1377838-00-0
2-(4-(piperidin-1-yl)phenyl)ethyl 5-chloro-3-ethyl-1H-indole-2-carboxylate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jm201485c

Reference yield:

: 41841-16-1
(4-bromo-phenyl)-acetic acid methyl ester

: 1377838-00-0
2-(4-(piperidin-1-yl)phenyl)ethyl 5-chloro-3-ethyl-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos / toluene / 12 h / 110 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; caesium carbonate; dicyclohexyl-carbodiimide; XPhos; In tetrahydrofuran; dichloromethane; toluene; 1: Buchwald-Hartwig amination;
DOI:10.1021/jm201485c

Reference yield:

: 26577-55-9
methyl 2-(4-(piperidin-1-yl)phenyl)acetate

: 1377838-00-0
2-(4-(piperidin-1-yl)phenyl)ethyl 5-chloro-3-ethyl-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

With dmap; lithium aluminium tetrahydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm201485c