N-(quinolin-8-yl)furan-2-carboxamide

Base Information

Chemical Name:N-(quinolin-8-yl)furan-2-carboxamide
CAS No.:304884-82-0
Molecular Formula:C₁₄H₁₀N₂O₂
Molecular Weight:238.246
Hs Code.:
DSSTox Substance ID:DTXSID001300685
Nikkaji Number:J3.505.153H
Mol file:304884-82-0.mol

Synonyms:N-(quinolin-8-yl)furan-2-carboxamide;N-quinolin-8-ylfuran-2-carboxamide;304884-82-0;Oprea1_450224;Oprea1_476282;N-(8-quinolinyl)-2-furamide;N~2~-(8-quinolyl)-2-furamide;DTXSID001300685;N-8-Quinolinyl-2-furancarboxamide;N-(8-Quinolyl)-2-furancarboxamide;STK324566;AKOS000462623;CCG-122083;J3.505.153H;AN-652/40072456;Z28487300

Suppliers and Price of N-(quinolin-8-yl)furan-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(quinolin-8-yl)furan-2-carboxamide

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:238.074227566
Heavy Atom Count:18
Complexity:308

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC2=C(C(=C1)NC(=O)C3=CC=CO3)N=CC=C2

Technology Process of N-(quinolin-8-yl)furan-2-carboxamide

There total 3 articles about N-(quinolin-8-yl)furan-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 527-69-5
2-furancarbonyl chloride

: 578-66-5
8-amino quinoline

: 304884-82-0
N-(quinolin-8-yl)furan-2-carboxamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/adsc.201600664

Reference yield: 74.0%

: 88-14-2
2-furanoic acid

: 578-66-5
8-amino quinoline

: 304884-82-0
N-(quinolin-8-yl)furan-2-carboxamide

Guidance literature:: 2-furanoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 25 ℃; for 3h; Schlenk technique; Inert atmosphere;

8-amino quinoline; With triethylamine; In dichloromethane; at 0 - 25 ℃; for 16h; Schlenk technique; Inert atmosphere;
DOI:10.1002/ejoc.202100580

Reference yield:

: 88-14-2
2-furanoic acid

: 304884-82-0
N-(quinolin-8-yl)furan-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 24 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 20 °C

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1002/ejoc.201500249