N-(((2R)-4-((5-amino-2-thiophenyl)sulfonyl)-1-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyrimidinyl)-2-piperazinyl)methyl)-N-phenylmethanesulfonamide

Base Information

Chemical Name:N-(((2R)-4-((5-amino-2-thiophenyl)sulfonyl)-1-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyrimidinyl)-2-piperazinyl)methyl)-N-phenylmethanesulfonamide
CAS No.:1361224-05-6
Molecular Formula:C₂₃H₂₄F₆N₆O₅S₃
Molecular Weight:674.669
Hs Code.:

N-(((2R)-4-((5-amino-2-thiophenyl)sulfonyl)-1-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyrimidinyl)-2-piperazinyl)methyl)-N-phenylmethanesulfonamide

Synonyms:N-(((2R)-4-((5-amino-2-thiophenyl)sulfonyl)-1-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyrimidinyl)-2-piperazinyl)methyl)-N-phenylmethanesulfonamide

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Chemical Property of N-(((2R)-4-((5-amino-2-thiophenyl)sulfonyl)-1-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyrimidinyl)-2-piperazinyl)methyl)-N-phenylmethanesulfonamide

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Technology Process of N-(((2R)-4-((5-amino-2-thiophenyl)sulfonyl)-1-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyrimidinyl)-2-piperazinyl)methyl)-N-phenylmethanesulfonamide

There total 9 articles about N-(((2R)-4-((5-amino-2-thiophenyl)sulfonyl)-1-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyrimidinyl)-2-piperazinyl)methyl)-N-phenylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361224-11-4
N-(((2R)-4-((5-nitro-2-thiophenyl)sulfonyl)-1-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyrimidinyl)-2-piperazinyl)methyl)-N-phenylmethanesulfonamide

: 1361224-05-6
N-(((2R)-4-((5-amino-2-thiophenyl)sulfonyl)-1-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyrimidinyl)-2-piperazinyl)methyl)-N-phenylmethanesulfonamide

Guidance literature:: N-(((2R)-4-((5-nitro-2-thiophenyl)sulfonyl)-1-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyrimidinyl)-2-piperazinyl)methyl)-N-phenylmethanesulfonamide; With iron; acetic acid; at 50 ℃; for 0.666667h;

With sodium hydrogencarbonate; In water; at 20 ℃;

Reference yield:

: 663598-21-8
(+)-[(2R)-1,4-dibenzylpiperazin-2-yl]methanol

: 1361224-05-6
N-(((2R)-4-((5-amino-2-thiophenyl)sulfonyl)-1-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyrimidinyl)-2-piperazinyl)methyl)-N-phenylmethanesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2.1: potassium carbonate / methanol / 0.5 h / 140 °C / sealed vial; microwave irradiation

3.1: triethylamine / dmap / dichloromethane / 3.5 h / 20 °C

4.1: hydrogen; acetic acid / palladium 10% on activated carbon / ethyl acetate; ethanol / 28.5 h / 20 - 50 °C

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C

6.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 h / 100 °C / sealed vial

7.1: trifluoroacetic acid / dichloromethane / 0.58 h / 20 °C

7.2: 0.17 h / 20 °C

7.3: 0.67 h / 20 °C

8.1: acetic acid; iron / 0.67 h / 50 °C

8.2: 20 °C

With hydrogen; iron; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dmap; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 1361222-15-2
((2R)-1,4-dibenzyl-2-piperazinyl)methyl methanesulfonate

: 1361224-05-6
N-(((2R)-4-((5-amino-2-thiophenyl)sulfonyl)-1-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyrimidinyl)-2-piperazinyl)methyl)-N-phenylmethanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / methanol / 0.5 h / 140 °C / sealed vial; microwave irradiation

2.1: triethylamine / dmap / dichloromethane / 3.5 h / 20 °C

3.1: hydrogen; acetic acid / palladium 10% on activated carbon / ethyl acetate; ethanol / 28.5 h / 20 - 50 °C

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C

5.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 h / 100 °C / sealed vial

6.1: trifluoroacetic acid / dichloromethane / 0.58 h / 20 °C

6.2: 0.17 h / 20 °C

6.3: 0.67 h / 20 °C

7.1: acetic acid; iron / 0.67 h / 50 °C

7.2: 20 °C

With hydrogen; iron; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dmap; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate;