(S)-tert-butyl 3-(2-(2-methoxy-5-methylphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate

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Chemical Name:(S)-tert-butyl 3-(2-(2-methoxy-5-methylphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate
CAS No.:1146160-29-3
Molecular Formula:C₂₅H₃₀N₄O₃
Molecular Weight:434.538
Hs Code.:

Synonyms:(S)-tert-butyl 3-(2-(2-methoxy-5-methylphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 3-(2-(2-methoxy-5-methylphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate

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Technology Process of (S)-tert-butyl 3-(2-(2-methoxy-5-methylphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate

There total 3 articles about (S)-tert-butyl 3-(2-(2-methoxy-5-methylphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1146160-27-1
(S)-tert-butyl 3-(2-chloroquinazolin-4-ylamino)pyrrolidine-1-carboxylate

: 127972-00-3
2-methoxy-5-methylphenyl boronic acid

: 1146160-29-3
(S)-tert-butyl 3-(2-(2-methoxy-5-methylphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; butan-1-ol; for 17h; Heating / reflux;

Reference yield:

: 607-68-1
2,4-dichloroquinazoline

: 1146160-29-3
(S)-tert-butyl 3-(2-(2-methoxy-5-methylphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 36 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; butan-1-ol / 17 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; In dichloromethane; toluene; butan-1-ol; 2: Suzuki-Miyaura reaction;
DOI:10.1021/jm101150b

Reference yield:

: 86-96-4
1,2,3,4-tetrahydro-quinazoline-2,4-dione

: 1146160-29-3
(S)-tert-butyl 3-(2-(2-methoxy-5-methylphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 48 h / 20 °C / Reflux

2: triethylamine / dichloromethane / 36 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; butan-1-ol / 17 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; trichlorophosphate; In dichloromethane; toluene; butan-1-ol; 3: Suzuki-Miyaura reaction;
DOI:10.1021/jm101150b