6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-(3,4-difluorophenyl)imidazo[1,2-a]pyridine

Base Information

Chemical Name:6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-(3,4-difluorophenyl)imidazo[1,2-a]pyridine
CAS No.:1198273-67-4
Molecular Formula:C₂₆H₂₆F₄N₂OSi
Molecular Weight:486.584
Hs Code.:

Synonyms:6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-(3,4-difluorophenyl)imidazo[1,2-a]pyridine

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Chemical Property of 6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-(3,4-difluorophenyl)imidazo[1,2-a]pyridine

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Technology Process of 6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-(3,4-difluorophenyl)imidazo[1,2-a]pyridine

There total 4 articles about 6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-(3,4-difluorophenyl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40706-98-7
3,4-difluorophenacyl bromide

: 1198211-11-8
5-[3-(tert-butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]pyridin-2-ylamine

: 1198273-67-4
6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-(3,4-difluorophenyl)imidazo[1,2-a]pyridine

Guidance literature:: With sodium hydrogencarbonate; In pentan-1-ol; at 80 ℃; for 16h;

Reference yield:

: 438050-05-6
(3-bromo-2,6-difluorophenyl)methanol

: 1198273-67-4
6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-(3,4-difluorophenyl)imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / tetrahydrofuran / 24 h / 20 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

3: sodium hydrogencarbonate / pentan-1-ol / 16 h / 80 °C

With 1H-imidazole; sodium hydrogencarbonate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; pentan-1-ol; water; N,N-dimethyl-formamide;

Reference yield:

: 398456-82-1
3-bromo-2,6-difluoro-benzaldehyde

: 1198273-67-4
6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-(3,4-difluorophenyl)imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; sodium tetrahydroborate / methanol / 1 h / 20 °C / Cooling with ice

2: 1H-imidazole / tetrahydrofuran / 24 h / 20 °C

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

4: sodium hydrogencarbonate / pentan-1-ol / 16 h / 80 °C

With 1H-imidazole; methanol; sodium tetrahydroborate; sodium hydrogencarbonate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; pentan-1-ol; water; N,N-dimethyl-formamide;