ethyl (E)-3-{1-[3'-(1-adamantyl)-4'-hydroxyphenyl]piperidin-4-yl}-2-propenoate

Base Information

Chemical Name:ethyl (E)-3-{1-[3'-(1-adamantyl)-4'-hydroxyphenyl]piperidin-4-yl}-2-propenoate
CAS No.:1308280-23-0
Molecular Formula:C₂₆H₃₅NO₃
Molecular Weight:409.569
Hs Code.:

Synonyms:ethyl (E)-3-{1-[3'-(1-adamantyl)-4'-hydroxyphenyl]piperidin-4-yl}-2-propenoate

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Chemical Property of ethyl (E)-3-{1-[3'-(1-adamantyl)-4'-hydroxyphenyl]piperidin-4-yl}-2-propenoate

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Technology Process of ethyl (E)-3-{1-[3'-(1-adamantyl)-4'-hydroxyphenyl]piperidin-4-yl}-2-propenoate

There total 5 articles about ethyl (E)-3-{1-[3'-(1-adamantyl)-4'-hydroxyphenyl]piperidin-4-yl}-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1308280-19-4
ethyl (E)-3-{1-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-4-piperidinyl}-2-propenoate

: 1308280-23-0
ethyl (E)-3-{1-[3'-(1-adamantyl)-4'-hydroxyphenyl]piperidin-4-yl}-2-propenoate

Guidance literature:: With boron tribromide; In dichloromethane; at -78 ℃; Inert atmosphere;
DOI:10.1021/jm200051z

Reference yield:

: 736992-49-7
2-(1-adamantyl)-1-benzyloxy-4-bromobenzene

: 1308280-23-0
ethyl (E)-3-{1-[3'-(1-adamantyl)-4'-hydroxyphenyl]piperidin-4-yl}-2-propenoate

Guidance literature:: Multi-step reaction with 4 steps

1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 19.5 h / 111 °C

2: diisobutylaluminium hydride / hexane; dichloromethane / 1 h / -78 °C

3: toluene / 15.7 h / Reflux

4: boron tribromide / dichloromethane / -78 °C / Inert atmosphere

With palladium diacetate; boron tribromide; diisobutylaluminium hydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In hexane; dichloromethane; toluene; 3: Wittig reaction;
DOI:10.1021/jm200051z

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 1308280-23-0
ethyl (E)-3-{1-[3'-(1-adamantyl)-4'-hydroxyphenyl]piperidin-4-yl}-2-propenoate

Guidance literature:: Multi-step reaction with 4 steps

1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 19.5 h / 111 °C

2: diisobutylaluminium hydride / hexane; dichloromethane / 1 h / -78 °C

3: toluene / 15.7 h / Reflux

4: boron tribromide / dichloromethane / -78 °C / Inert atmosphere

With palladium diacetate; boron tribromide; diisobutylaluminium hydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In hexane; dichloromethane; toluene; 3: Wittig reaction;
DOI:10.1021/jm200051z