5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

Base Information

Chemical Name:5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide
CAS No.:1616925-60-0
Molecular Formula:C₃₄H₄₈N₄O₄Si
Molecular Weight:604.865
Hs Code.:

5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

Synonyms:5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

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Chemical Property of 5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

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Technology Process of 5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

There total 12 articles about 5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: N-(2-((tert-butyldimethylsilyl)oxy)ethyl)propan-2-amine

: 1616925-59-7
5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid

: 1616925-60-0
5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1616925-58-6
5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester

: 1616925-60-0
5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 16 h / Reflux

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 30379-55-6
benzyloxyacetic acid

: 1616925-60-0
5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 3 h / 0 - 20 °C

2: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

3: sodium methylate / methanol / 16 h / 0 - 20 °C

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 16 h / Reflux

5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With n-butyllithium; thionyl chloride; lithium hydroxide monohydrate; sodium methylate; diisopropylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide;