3-azido-2,4-dioxo-1-N-(3-methylbut-1-yl)-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Base Information

Chemical Name:3-azido-2,4-dioxo-1-N-(3-methylbut-1-yl)-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
CAS No.:151620-52-9
Molecular Formula:C₂₀H₂₁N₅O₂
Molecular Weight:363.419
Hs Code.:

Synonyms:3-azido-2,4-dioxo-1-N-(3-methylbut-1-yl)-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Suppliers and Price of 3-azido-2,4-dioxo-1-N-(3-methylbut-1-yl)-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-azido-2,4-dioxo-1-N-(3-methylbut-1-yl)-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-azido-2,4-dioxo-1-N-(3-methylbut-1-yl)-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

There total 3 articles about 3-azido-2,4-dioxo-1-N-(3-methylbut-1-yl)-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 151620-51-8
2,4-dioxo-1-N-(3-methylbut-1-yl)-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 151620-52-9
3-azido-2,4-dioxo-1-N-(3-methylbut-1-yl)-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: 2,4-dioxo-1-N-(3-methylbut-1-yl)-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 0.5h;

With 2,4,6-Triisopropylbenzenesulfonyl azide; In tetrahydrofuran; at -78 ℃; for 0.0833333h; Further stages.;
DOI:10.1021/jm990967h

Reference yield:

: 16156-55-1
3-methyl-1-butyl methanesulfonate

: 151620-52-9
3-azido-2,4-dioxo-1-N-(3-methylbut-1-yl)-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.75 h / 130 °C

1.2: dimethylformamide / 6 h / 150 °C

2.1: t-BuOK / tetrahydrofuran / 0.5 h / -78 °C

2.2: 2,4,6-triisopropylbenzenesulfonyl azide / tetrahydrofuran / 0.08 h / -78 °C

With potassium tert-butylate; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Alkylation / 2.1: Metallation / 2.2: Azidation;
DOI:10.1021/jm990967h

Reference yield:

: 22316-50-3
1-phenyl 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine

: 151620-52-9
3-azido-2,4-dioxo-1-N-(3-methylbut-1-yl)-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.75 h / 130 °C

1.2: dimethylformamide / 6 h / 150 °C

2.1: t-BuOK / tetrahydrofuran / 0.5 h / -78 °C

2.2: 2,4,6-triisopropylbenzenesulfonyl azide / tetrahydrofuran / 0.08 h / -78 °C

With potassium tert-butylate; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Alkylation / 2.1: Metallation / 2.2: Azidation;
DOI:10.1021/jm990967h