1,3-dimethyl-4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)-benzoyl]-5-hydroxypyrazole

Base Information

Chemical Name:1,3-dimethyl-4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)-benzoyl]-5-hydroxypyrazole
CAS No.:1070778-77-6
Molecular Formula:C₁₇H₂₁N₃O₄S
Molecular Weight:363.437
Hs Code.:

Synonyms:1,3-dimethyl-4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)-benzoyl]-5-hydroxypyrazole

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Chemical Property of 1,3-dimethyl-4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)-benzoyl]-5-hydroxypyrazole

Chemical Property:

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Technology Process of 1,3-dimethyl-4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)-benzoyl]-5-hydroxypyrazole

There total 2 articles about 1,3-dimethyl-4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)-benzoyl]-5-hydroxypyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070779-73-5
3-cyclopropylamino-2-methyl-4-(methylsulfonyl)benzoic acid

: 5203-77-0
1,3-dimethyl-1H-pyrazol-5-ol

: 1070778-77-6
1,3-dimethyl-4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)-benzoyl]-5-hydroxypyrazole

Guidance literature:: 3-cyclopropylamino-2-methyl-4-(methylsulfonyl)benzoic acid; 1,3-dimethyl-1H-pyrazol-5-ol; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 72h;

With trimethylsilyl cyanide; potassium cyanide; triethylamine; In acetonitrile; at 20 ℃; for 48h;

Reference yield:

: 118939-18-7
3-fluoro-2-methyl-4-(methylsulfonyl)benzoic acid

: 1070778-77-6
1,3-dimethyl-4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)-benzoyl]-5-hydroxypyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 24 h / 120 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 72 h / 20 °C

2.2: 48 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile;