(5-benzyl-4-phenyl-4H-[1,2,4]triazol-3-thio)-acetic acid hydrazide

Base Information

• Chemical Name: (5-benzyl-4-phenyl-4H-[1,2,4]triazol-3-thio)-acetic acid hydrazide
• CAS No.: 49656-92-0
• Molecular Formula: C₁₇H₁₇N₅OS
• Molecular Weight: 339.421
• Mol file: 49656-92-0.mol

Synonyms:(5-benzyl-4-phenyl-4H-[1,2,4]triazol-3-thio)-acetic acid hydrazide

Chemical Property of (5-benzyl-4-phenyl-4H-[1,2,4]triazol-3-thio)-acetic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (5-benzyl-4-phenyl-4H-[1,2,4]triazol-3-thio)-acetic acid hydrazide

There total 2 articles about (5-benzyl-4-phenyl-4H-[1,2,4]triazol-3-thio)-acetic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(5-benzyl-4-phenyl-4H-[1,2,4]triazol-3-thio)-acetic acid ethyl ester (401830-30-6) → (5-benzyl-4-phenyl-4H-[1,2,4]triazol-3-thio)-acetic acid hydrazide (49656-92-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Reflux;

DOI:10.3390/molecules15106759

Reference yield: 54.0%

→ (5-benzyl-4-phenyl-4H-[1,2,4]triazol-3-thio)-acetic acid hydrazide (49656-92-0)

Guidance literature:

Reference yield: 89.0%

Ethyl isothiocyanate (542-85-8) + (5-benzyl-4-phenyl-4H-[1,2,4]triazol-3-thio)-acetic acid hydrazide (49656-92-0) → 1-(2-(5-benzyl-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetyl)-4-ethylthiosemicarbazide (1041853-98-8)

Guidance literature:

In ethanol; for 2h; Heating;

DOI:10.1002/jhet.5570450339

upstream raw materials:

(5-benzyl-4-phenyl-4H-[1,2,4]triazol-3-thio)-acetic acid ethyl ester

Downstream raw materials:

1-(2-(5-benzyl-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetyl)-4-ethylthiosemicarbazide

1-(2-(5-benzyl-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetyl)-4-phenylthiosemicarbazide

1-(2-(5-benzyl-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetyl)-4-methylthiosemicarbazide

1-(2-(5-benzyl-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetyl)-4-cyclohexylthiosemi-carbazide