Chemical Property of Concanamycin B
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Boiling Point:960.2°C at 760 mmHg
- Flash Point:534.5°C
- PSA：225.92000
- Density:1.2g/cm3
- LogP:5.29410
- XLogP3:5.6
- Hydrogen Bond Donor Count:6
- Hydrogen Bond Acceptor Count:14
- Rotatable Bond Count:11
- Exact Mass:851.50310600
- Heavy Atom Count:60
- Complexity:1560
- Purity/Quality:
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98% *data from raw suppliers
Concanamycin B *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC=CC1C(C(CC(O1)(C(C)C(C(C)C2C(C=CC=C(CC(C(C(C(C(C=C(C=C(C(=O)O2)OC)C)C)O)C)O)C)C)OC)O)O)OC3CC(C(C(O3)C)OC(=O)N)O)C
- Isomeric SMILES:C/C=C/[C@@H]1[C@H]([C@@H](C[C@@](O1)([C@@H](C)[C@@H]([C@H](C)[C@@H]2[C@H](/C=C/C=C(/C[C@H]([C@@H]([C@@H]([C@@H]([C@@H](/C=C(/C=C(/C(=O)O2)\OC)\C)C)O)C)O)C)\C)OC)O)O)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)OC(=O)N)O)C
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Uses
Concanamycin B is a macrocyclic lactone originally isolated from Streptomyces diastatochromogenes in 1982 as a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A. Like other concanamycins and bafilomycins, concanamycin B inhibits vacuolar H(+)-ATPase. Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules and suppresses bone resorption in vitro. Concanamycin B is an antibiotic and inhibitor of vacuolar-type H+-ATPase.
