ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-hydroxymethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

Base Information

Chemical Name:ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-hydroxymethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
CAS No.:1194057-65-2
Molecular Formula:C₂₉H₃₂FN₃O₇
Molecular Weight:553.587
Hs Code.:

ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-hydroxymethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

Synonyms:ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-hydroxymethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

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Chemical Property of ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-hydroxymethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

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Technology Process of ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-hydroxymethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

There total 7 articles about ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-hydroxymethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1194057-64-1
ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-fomyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

: 1194057-65-2
ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-hydroxymethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-fomyl-4-oxo-1,4-dihydroquinoline-3-carboxylate; With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 120h; Inert atmosphere;

With water; sodium hydrogencarbonate; In dichloromethane; Inert atmosphere;

Reference yield:

: 452092-31-8
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic acid ethyl ester

: 1194057-65-2
ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-hydroxymethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 20 °C

2.1: triphenyl-arsane; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 10 h / 50 °C / Inert atmosphere

3.1: osmium(VIII) oxide; tert-butyl alcohol / 1,4-dioxane; water / 0.33 h / 40 °C

3.2: 28 h / 40 °C

3.3: 45 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 50 °C / Inert atmosphere

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 120 h / 20 °C / Inert atmosphere

5.2: Inert atmosphere

With osmium(VIII) oxide; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; tert-butyl alcohol; triphenyl-arsane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetonitrile;

Reference yield:

: 1194056-49-9
ethyl 1-cyclopropyl-6,7-difluoro-4-oxo-8-[(trifluoromethyl)sulfonyl]oxy-1,4-dihydroquinoline-3-carboxylate

: 1194057-65-2
ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-hydroxymethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenyl-arsane; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 10 h / 50 °C / Inert atmosphere

2.1: osmium(VIII) oxide; tert-butyl alcohol / 1,4-dioxane; water / 0.33 h / 40 °C

2.2: 28 h / 40 °C

2.3: 45 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 50 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 120 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

With osmium(VIII) oxide; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; tert-butyl alcohol; triphenyl-arsane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetonitrile;