Technology Process of 3-(4-carboxy-2-methoxy-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester
There total 10 articles about 3-(4-carboxy-2-methoxy-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: DL-10-camphorsulfonic acid / 1,4-dioxane / 3 h / 75 - 80 °C / Sealed tube
2: sodium methylate / methanol / 48 h / 25 °C
3: hydrogen / palladium 10% on activated carbon / dichloromethane; ethyl acetate; acetone
4: toluene / 4 h / 130 °C
5: potassium carbonate / methanol / 2 h / 85 °C
6: hydrogenchloride / water
With
hydrogenchloride; hydrogen; sodium methylate; potassium carbonate;
palladium 10% on activated carbon; DL-10-camphorsulfonic acid;
In
1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; acetone; toluene;
2: Aldol Condensation;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / dimethyl sulfoxide / 4 h / 25 °C
2: sodium methylate / methanol / 48 h / 25 °C
3: hydrogen / palladium 10% on activated carbon / dichloromethane; ethyl acetate; acetone
4: toluene / 4 h / 130 °C
5: potassium carbonate / methanol / 2 h / 85 °C
6: hydrogenchloride / water
With
hydrogenchloride; hydrogen; sodium methylate; potassium carbonate;
palladium 10% on activated carbon;
In
methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetone; toluene;
2: Aldol Condensation;
