2-(4-((1R,2R)-2-((3-fluoro-4-(1H-tetrazol-1-yl)benzyloxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Base Information

• Chemical Name: 2-(4-((1R,2R)-2-((3-fluoro-4-(1H-tetrazol-1-yl)benzyloxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine
• CAS No.: 1416365-82-6
• Molecular Formula: C₂₃H₂₈FN₇O₂
• Molecular Weight: 453.519
• Mol file: 1416365-82-6.mol

Synonyms:2-(4-((1R,2R)-2-((3-fluoro-4-(1H-tetrazol-1-yl)benzyloxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Chemical Property of 2-(4-((1R,2R)-2-((3-fluoro-4-(1H-tetrazol-1-yl)benzyloxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-((1R,2R)-2-((3-fluoro-4-(1H-tetrazol-1-yl)benzyloxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

There total 8 articles about 2-(4-((1R,2R)-2-((3-fluoro-4-(1H-tetrazol-1-yl)benzyloxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-(methoxymethyl)pyrimidine (1416366-34-1) + 4-((1R,2R)-2-((3-fluoro-4-(1H-tetrazol-1-yl)benzyloxy)methyl)cyclopropyl)piperidinium chloride (1416366-82-9) → 2-(4-((1R,2R)-2-((3-fluoro-4-(1H-tetrazol-1-yl)benzyloxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine (1416365-82-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 55 ℃;

Reference yield:

tert-butyl 4-((1R,2R)-2-((4-amino-3-fluorobenzyloxy)methyl)cyclopropyl)piperidine-1-carboxylate (1416366-80-7) → 2-(4-((1R,2R)-2-((3-fluoro-4-(1H-tetrazol-1-yl)benzyloxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine (1416365-82-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide; acetic acid / 3 h / 100 °C / Inert atmosphere

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 55 °C

With hydrogenchloride; sodium azide; caesium carbonate; acetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acsmedchemlett.5b00207

Reference yield:

tert-butyl 4-((1R,2R)-2-((3-fluoro-4-(1H-tetrazol-1-yl)benzyloxy)methyl)cyclopropyl)piperidine-1-carboxylate (1416366-81-8) → 2-(4-((1R,2R)-2-((3-fluoro-4-(1H-tetrazol-1-yl)benzyloxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine (1416365-82-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 55 °C

With hydrogenchloride; caesium carbonate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acsmedchemlett.5b00207

upstream raw materials:

2-chloro-5-hydroxymethyl-pyrimidine

2-chloro-5-(methoxymethyl)pyrimidine

4-((1R,2R)-2-((3-fluoro-4-(1H-tetrazol-1-yl)benzyloxy)methyl)cyclopropyl)piperidinium chloride

tert-butyl 4-((1R,2R)-2-((4-amino-3-fluorobenzyloxy)methyl)cyclopropyl)piperidine-1-carboxylate