(S)-3-{6-[(ethyl-phenylamino)-methyl]-pyridin-2-yl}-2-hydroxy-2-phenylpropionic acid

Base Information

Chemical Name:(S)-3-{6-[(ethyl-phenylamino)-methyl]-pyridin-2-yl}-2-hydroxy-2-phenylpropionic acid
CAS No.:1082553-06-7
Molecular Formula:C₂₃H₂₄N₂O₃
Molecular Weight:376.455
Hs Code.:

Synonyms:(S)-3-{6-[(ethyl-phenylamino)-methyl]-pyridin-2-yl}-2-hydroxy-2-phenylpropionic acid

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Chemical Property of (S)-3-{6-[(ethyl-phenylamino)-methyl]-pyridin-2-yl}-2-hydroxy-2-phenylpropionic acid

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Technology Process of (S)-3-{6-[(ethyl-phenylamino)-methyl]-pyridin-2-yl}-2-hydroxy-2-phenylpropionic acid

There total 3 articles about (S)-3-{6-[(ethyl-phenylamino)-methyl]-pyridin-2-yl}-2-hydroxy-2-phenylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1082553-07-8
(2S,5S)-2-tert-butyl-5-((6-((methyl(phenyl)amino)methyl)pyridin-2-yl)methyl)-5-phenyl-1,3-dioxolan-4-one

: 1082553-06-7
(S)-3-{6-[(ethyl-phenylamino)-methyl]-pyridin-2-yl}-2-hydroxy-2-phenylpropionic acid

Guidance literature:: With lithium hydroxide; water; In tetrahydrofuran; for 17h; Reflux;
DOI:10.1055/s-2008-1078248

Reference yield:

: 103-69-5
N-ethyl-N-phenylamine

: 1082553-06-7
(S)-3-{6-[(ethyl-phenylamino)-methyl]-pyridin-2-yl}-2-hydroxy-2-phenylpropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / 0 °C

1.2: 0.33 h / -40 °C

1.3: 5 h / -40 °C

2.1: lithium hydroxide / tetrahydrofuran; water / 17 h / 105 °C

2.2: pH 7

With n-butyllithium; lithium hydroxide; In tetrahydrofuran; hexane; water;
DOI:10.1039/c2ob25834j

Reference yield:

: 831210-10-7
(2S,5S)-5-((6-(bromomethyl)pyridin-2-yl)methyl)-2-tert-butyl-5-phenyl-1,3-dioxolan-4-one

: 1082553-06-7
(S)-3-{6-[(ethyl-phenylamino)-methyl]-pyridin-2-yl}-2-hydroxy-2-phenylpropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / 0 °C

1.2: 0.33 h / -40 °C

1.3: 5 h / -40 °C

2.1: lithium hydroxide / tetrahydrofuran; water / 17 h / 105 °C

2.2: pH 7

With n-butyllithium; lithium hydroxide; In tetrahydrofuran; hexane; water;
DOI:10.1039/c2ob25834j