Technology Process of cyclo[Pmp-Tyr(Me)-Ile-Thr-Asn-Cys]-Pro-Orn(Boc)-Phe(3I,4N3)-NH2
There total 8 articles about cyclo[Pmp-Tyr(Me)-Ile-Thr-Asn-Cys]-Pro-Orn(Boc)-Phe(3I,4N3)-NH2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: aq. NH3; N-methylmorpholine; isobutyl chlorocarbonate / dimethylformamide / 0.17 h
2.1: TFA / CH2Cl2
3.1: 89 percent / PyBOP; iPr2NEt / dimethylformamide
4.1: Et2NH / dimethylformamide
5.1: 90 percent / H2 / 10percent Pd/C / methanol
6.1: ICl / methanol
7.1: NaNO2; aq. HCl / 0.17 h / 0 °C
7.2: NaN3 / 20 °C
8.1: PyBOP; iPr2NEt
With
4-methyl-morpholine; hydrogenchloride; ammonium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; Iodine monochloride; diethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite; isobutyl chloroformate;
10percent Pd/C;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010125u
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 89 percent / PyBOP; iPr2NEt / dimethylformamide
2.1: Et2NH / dimethylformamide
3.1: 90 percent / H2 / 10percent Pd/C / methanol
4.1: ICl / methanol
5.1: NaNO2; aq. HCl / 0.17 h / 0 °C
5.2: NaN3 / 20 °C
6.1: PyBOP; iPr2NEt
With
hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; Iodine monochloride; diethylamine; N-ethyl-N,N-diisopropylamine; sodium nitrite;
10percent Pd/C;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm010125u
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: TFA / CH2Cl2
2.1: 89 percent / PyBOP; iPr2NEt / dimethylformamide
3.1: Et2NH / dimethylformamide
4.1: 90 percent / H2 / 10percent Pd/C / methanol
5.1: ICl / methanol
6.1: NaNO2; aq. HCl / 0.17 h / 0 °C
6.2: NaN3 / 20 °C
7.1: PyBOP; iPr2NEt
With
hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; Iodine monochloride; diethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite;
10percent Pd/C;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010125u
