3-(4-amino-5-methyl-3'H-dispiro[cyclopropane-1,2'-indene-1',2-imidazol]-6'-yl)-5-chlorobenzonitrile

Base Information

Chemical Name:3-(4-amino-5-methyl-3'H-dispiro[cyclopropane-1,2'-indene-1',2-imidazol]-6'-yl)-5-chlorobenzonitrile
CAS No.:1383983-62-7
Molecular Formula:C₂₁H₁₇ClN₄
Molecular Weight:360.846
Hs Code.:

Synonyms:3-(4-amino-5-methyl-3'H-dispiro[cyclopropane-1,2'-indene-1',2-imidazol]-6'-yl)-5-chlorobenzonitrile

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Chemical Property of 3-(4-amino-5-methyl-3'H-dispiro[cyclopropane-1,2'-indene-1',2-imidazol]-6'-yl)-5-chlorobenzonitrile

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Technology Process of 3-(4-amino-5-methyl-3'H-dispiro[cyclopropane-1,2'-indene-1',2-imidazol]-6'-yl)-5-chlorobenzonitrile

There total 2 articles about 3-(4-amino-5-methyl-3'H-dispiro[cyclopropane-1,2'-indene-1',2-imidazol]-6'-yl)-5-chlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1212021-11-8
3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

: 1383983-61-6
6'-bromo-5-methyl-3'H-dispiro[cyclopropane-1,2'-indene-1',2-imidazol]-4-amine

: 1383983-62-7
3-(4-amino-5-methyl-3'H-dispiro[cyclopropane-1,2'-indene-1',2-imidazol]-6'-yl)-5-chlorobenzonitrile

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; water; at 130 ℃; for 1h; Inert atmosphere; Sealed vial; Microwave irradiation;

Reference yield:

: 289039-30-1
3-chloro-5-iodobenzonitrile

: 1383983-62-7
3-(4-amino-5-methyl-3'H-dispiro[cyclopropane-1,2'-indene-1',2-imidazol]-6'-yl)-5-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / Inert atmosphere; Reflux

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 1 h / 130 °C / Inert atmosphere; Sealed vial; Microwave irradiation

With potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water;