(1S,2S)-N-acetyl-N'-methyl-1,2-bis(trifluoromethanesulfonamido)cyclohexane

Base Information

• Chemical Name: (1S,2S)-N-acetyl-N'-methyl-1,2-bis(trifluoromethanesulfonamido)cyclohexane
• CAS No.: 498542-97-5
• Molecular Formula: C₁₁H₁₆F₆N₂O₅S₂
• Molecular Weight: 434.381
• Mol file: 498542-97-5.mol

Synonyms:(1S,2S)-N-acetyl-N'-methyl-1,2-bis(trifluoromethanesulfonamido)cyclohexane

Chemical Property of (1S,2S)-N-acetyl-N'-methyl-1,2-bis(trifluoromethanesulfonamido)cyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S)-N-acetyl-N'-methyl-1,2-bis(trifluoromethanesulfonamido)cyclohexane

There total 2 articles about (1S,2S)-N-acetyl-N'-methyl-1,2-bis(trifluoromethanesulfonamido)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (1S,2S)-N-acetyl-1,2-bis(trifluoromethanesulfonamido) cyclohexane (498542-91-9) → (1S,2S)-N-acetyl-N'-methyl-1,2-bis(trifluoromethanesulfonamido)cyclohexane (498542-97-5)

Guidance literature:

In diethyl ether; at 20 ℃;

DOI:10.1002/anie.200453956 DOI:10.1039/b504200c

Reference yield:

C,C,C-trifluoro-N-(2-trifluoromethanesulfonylaminocyclohexyl)methanesulfonamide (153077-87-3) → (1S,2S)-N-acetyl-N'-methyl-1,2-bis(trifluoromethanesulfonamido)cyclohexane (498542-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / Et₃N / diethyl ether / 3 h / 0 °C

2: 100 percent / diethyl ether / 20 °C

With triethylamine; In diethyl ether;

DOI:10.1039/b504200c

Reference yield:

rac-methylbenzylamine (618-36-0) + (1S,2S)-N-acetyl-N'-methyl-1,2-bis(trifluoromethanesulfonamido)cyclohexane (498542-97-5) → (S)-1-phenyl-ethylamine (2627-86-3) + (R)-1-phenyl-ethyl-amine (3886-69-9) + N-acetyl-1-phenylethylamine (36283-44-0,6284-14-6) + (S)-N-acetyl-1-phenylethylamine (19144-86-6,6284-14-6)

Guidance literature:

In toluene; at 20 ℃; for 2h; Title compound not separated from byproducts;

DOI:10.1002/anie.200453956

upstream raw materials:

diazomethane

(1S,2S)-N-acetyl-1,2-bis(trifluoromethanesulfonamido) cyclohexane

C,C,C-trifluoro-N-(2-trifluoromethanesulfonylaminocyclohexyl)methanesulfonamide

Downstream raw materials:

(S)-1-phenyl-ethylamine

(R)-1-phenyl-ethyl-amine

N-acetyl-1-phenylethylamine

(S)-N-acetyl-1-phenylethylamine