methyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexylthio)-4-methyl-1H-pyrrole-3-carboxylate

Base Information

Chemical Name:methyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexylthio)-4-methyl-1H-pyrrole-3-carboxylate
CAS No.:1561965-30-7
Molecular Formula:C₂₇H₃₇NO₂S
Molecular Weight:439.662
Hs Code.:

Synonyms:methyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexylthio)-4-methyl-1H-pyrrole-3-carboxylate

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Chemical Property of methyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexylthio)-4-methyl-1H-pyrrole-3-carboxylate

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Technology Process of methyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexylthio)-4-methyl-1H-pyrrole-3-carboxylate

There total 5 articles about methyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexylthio)-4-methyl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 2550-40-5
1,2-dicyclohexyl disulfide

: 1561965-29-4
methyl 5-bromo-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylate

: 1561965-30-7
methyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexylthio)-4-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: methyl 5-bromo-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylate; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

1,2-dicyclohexyl disulfide; In tetrahydrofuran; at -78 ℃; for 2.5h;

Reference yield:

: 129316-09-2
1,3-dibromo-5-t-butylbenzene

: 1561965-30-7
methyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexylthio)-4-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 90 °C / Inert atmosphere

2.1: trifluoroacetic acid; diethylzinc / hexane; dichloromethane / 0 °C

2.2: 0.5 h / 0 - 20 °C

3.1: potassium phosphate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / toluene / Inert atmosphere; Reflux

4.1: N-Bromosuccinimide / tetrahydrofuran / 0.25 h / -78 °C

4.2: 21 h / 0 - 50 °C

5.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

5.2: 2.5 h / -78 °C

With potassium phosphate; N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; diethylzinc; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; toluene;

Reference yield:

: 1609079-05-1
methyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylate

: 1561965-30-7
methyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexylthio)-4-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 0.25 h / -78 °C

1.2: 21 h / 0 - 50 °C

2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 2.5 h / -78 °C

With N-Bromosuccinimide; n-butyllithium; In tetrahydrofuran;