2-chloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Base Information

Chemical Name:2-chloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate
CAS No.:85923-43-9
Molecular Formula:C₂₅H₂₇ClN₂O₅S
Molecular Weight:503.019
Hs Code.:

Synonyms:2-chloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

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Chemical Property of 2-chloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

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Technology Process of 2-chloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

There total 4 articles about 2-chloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 627-11-2
2-Chloroethyl chloroformate

: 85923-42-8
N-<<(4-methoxybenzenesulfonyl)-2-methyl-1H-indol-3-yl>methylene>-4-pentenylamine

: 85923-43-9
2-chloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In chlorobenzene; 1.) 0 deg C -> 135 deg C, 35 min, 2.) 135 deg C, 40 min;
DOI:10.1021/ja00352a037

Reference yield:

: 5416-80-8
2-methyl-1H-indole-3-carbaldehyde

: 85923-43-9
2-chloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium hydride, 2.) imidazole / 1.) glyme, 20 deg C, 1.5 h, reflux, 15 min, 2.) 20 deg C, 15 h

2: 2.) Na₂SO₄ / 1.) benzene, 1 h, 2.) 2 h

3: 92 percent / diisopropylethylamine / chlorobenzene / 1.) 0 deg C -> 135 deg C, 35 min, 2.) 135 deg C, 40 min

With 1H-imidazole; sodium hydride; sodium sulfate; N-ethyl-N,N-diisopropylamine; In chlorobenzene;
DOI:10.1021/ja00352a037

Reference yield:

: 80664-26-2
N-<(4-methoxyphenyl)sulfonyl>-2-methylindole-3-carboxaldehyde

: 85923-43-9
2-chloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) Na₂SO₄ / 1.) benzene, 1 h, 2.) 2 h

2: 92 percent / diisopropylethylamine / chlorobenzene / 1.) 0 deg C -> 135 deg C, 35 min, 2.) 135 deg C, 40 min

With sodium sulfate; N-ethyl-N,N-diisopropylamine; In chlorobenzene;
DOI:10.1021/ja00352a037