(-)-(1'S,2S,4E)-13-benzyloxy-2-(1'-hydroxy-ethyl)-tridec-4-enoic acid hydrazide

Base Information

Chemical Name:(-)-(1'S,2S,4E)-13-benzyloxy-2-(1'-hydroxy-ethyl)-tridec-4-enoic acid hydrazide
CAS No.:933786-38-0
Molecular Formula:C₂₂H₃₆N₂O₃
Molecular Weight:376.539
Hs Code.:

Synonyms:(-)-(1'S,2S,4E)-13-benzyloxy-2-(1'-hydroxy-ethyl)-tridec-4-enoic acid hydrazide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-(1'S,2S,4E)-13-benzyloxy-2-(1'-hydroxy-ethyl)-tridec-4-enoic acid hydrazide

Chemical Property:

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Technology Process of (-)-(1'S,2S,4E)-13-benzyloxy-2-(1'-hydroxy-ethyl)-tridec-4-enoic acid hydrazide

There total 7 articles about (-)-(1'S,2S,4E)-13-benzyloxy-2-(1'-hydroxy-ethyl)-tridec-4-enoic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: (-)-(1'S,4E)-13-benzyloxy-2-(1'-hydroxy-ethyl)-tridec-4-enoic acid methyl ester

: 933786-38-0
(-)-(1'S,2S,4E)-13-benzyloxy-2-(1'-hydroxy-ethyl)-tridec-4-enoic acid hydrazide

Guidance literature:: With dmap; hydrazine hydrate; In methanol; at 115 ℃; for 24h;
DOI:10.1016/j.tet.2007.01.008

Reference yield:

: 933786-60-8
(2E)-11-benzyloxy-1-bromo-undec-2-en

: 933786-38-0
(-)-(1'S,2S,4E)-13-benzyloxy-2-(1'-hydroxy-ethyl)-tridec-4-enoic acid hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiHMDS; DMPU / tetrahydrofuran / 0.5 h / -60 °C

1.2: tetrahydrofuran / 4 h / 0 °C

2.1: 71 percent / hydrazine hydrate; 4-(dimethylamino)-pyridine / methanol / 24 h / 115 °C

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hydrazine hydrate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;
DOI:10.1016/j.tet.2007.01.008

Reference yield:

: 933786-59-5
(+/-)-11-benzyloxy-undec-1-en-3-ol

: 933786-38-0
(-)-(1'S,2S,4E)-13-benzyloxy-2-(1'-hydroxy-ethyl)-tridec-4-enoic acid hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: PBr₃; pyridine / petroleum ether / 1.33 h / 20 °C

2.1: LiHMDS; DMPU / tetrahydrofuran / 0.5 h / -60 °C

2.2: tetrahydrofuran / 4 h / 0 °C

3.1: 71 percent / hydrazine hydrate; 4-(dimethylamino)-pyridine / methanol / 24 h / 115 °C

With pyridine; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; phosphorus tribromide; hydrazine hydrate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; Petroleum ether;
DOI:10.1016/j.tet.2007.01.008