N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

Base Information

• Chemical Name: N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine
• CAS No.: 1369583-90-3
• Molecular Formula: C₃₃H₃₉N₃O₃S
• Molecular Weight: 557.757
• Mol file: 1369583-90-3.mol

Synonyms:N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

Chemical Property of N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

There total 6 articles about N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.6%

1-(2-Methoxyphenyl)piperazine (35386-24-4) + C22H24ClNO2S (1369583-83-4) → N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine (1369583-90-3)

Guidance literature:

With triethylamine; sodium iodide; In acetonitrile; at 80 ℃; for 4h;

Reference yield:

2-Acetylthiophene (88-15-3,97511-16-5) → N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine (1369583-90-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide / 3 h / 100 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux

3.1: potassium hydroxide / 0.5 h / 20 °C

3.2: 12 h / 90 °C

4.1: sodium hydrogencarbonate / toluene / 10 h / 90 °C

5.1: dimethyl sulfoxide; potassium hydroxide / 6 h / 80 °C

6.1: triethylamine / dichloromethane / 1.5 h / 20 °C

7.1: triethylamine; sodium iodide / acetonitrile / 4 h / 80 °C

With lithium aluminium tetrahydride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; N,N-dimethyl-formamide; sodium iodide; potassium hydroxide; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

Reference yield:

N-methyl-N-ethyloxyacyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine (1049751-94-1) → N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine (1369583-90-3)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethyl sulfoxide; potassium hydroxide / 6 h / 80 °C

2: triethylamine / dichloromethane / 1.5 h / 20 °C

3: triethylamine; sodium iodide / acetonitrile / 4 h / 80 °C

With dimethyl sulfoxide; triethylamine; sodium iodide; potassium hydroxide; In dichloromethane; acetonitrile;

upstream raw materials:

2-Acetylthiophene

3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol

1-(2-Methoxyphenyl)piperazine

C₂₂H₂₄ClNO₂S

Downstream raw materials:

N-[4-(4-(2-methoxyphenylpiperazinyl))butyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine