3-(3-(bis(2-chloroethyl)amino)-4-methoxyphenyl)-7-hydroxy-4H-chromen-4-one

Base Information

Chemical Name:3-(3-(bis(2-chloroethyl)amino)-4-methoxyphenyl)-7-hydroxy-4H-chromen-4-one
CAS No.:1393723-09-5
Molecular Formula:C₂₀H₁₉Cl₂NO₄
Molecular Weight:408.281
Hs Code.:

Synonyms:3-(3-(bis(2-chloroethyl)amino)-4-methoxyphenyl)-7-hydroxy-4H-chromen-4-one

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Chemical Property of 3-(3-(bis(2-chloroethyl)amino)-4-methoxyphenyl)-7-hydroxy-4H-chromen-4-one

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Technology Process of 3-(3-(bis(2-chloroethyl)amino)-4-methoxyphenyl)-7-hydroxy-4H-chromen-4-one

There total 3 articles about 3-(3-(bis(2-chloroethyl)amino)-4-methoxyphenyl)-7-hydroxy-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1393722-92-3
3-(3-(bis(2-hydroxyethyl)amino)-4-methoxyphenyl)-7-hydroxy-4H-chromen-4-one

: 1393723-09-5
3-(3-(bis(2-chloroethyl)amino)-4-methoxyphenyl)-7-hydroxy-4H-chromen-4-one

Guidance literature:: With thionyl chloride; In dichloromethane; for 1.5h; Reflux;
DOI:10.1016/j.ejmech.2012.04.039

Reference yield:

: 908104-37-0
7-hydroxy-3-(4-methoxy-3-nitrophenyl)-4H-chromen-4-one

: 1393723-09-5
3-(3-(bis(2-chloroethyl)amino)-4-methoxyphenyl)-7-hydroxy-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone / Reflux

2: acetic acid; zinc / ethanol / Reflux

3: acetic acid / 0 - 20 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C / 760.05 Torr

5: thionyl chloride / dichloromethane / 1.5 h / Reflux

With thionyl chloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; zinc; In methanol; ethanol; dichloromethane; acetone;
DOI:10.1016/j.ejmech.2012.04.039

Reference yield:

: 485-72-3
7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on

: 1393723-09-5
3-(3-(bis(2-chloroethyl)amino)-4-methoxyphenyl)-7-hydroxy-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid; nitric acid; acetic acid / 12 h / 50 °C

2: potassium carbonate / acetone / Reflux

3: acetic acid; zinc / ethanol / Reflux

4: acetic acid / 0 - 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C / 760.05 Torr

6: thionyl chloride / dichloromethane / 1.5 h / Reflux

With thionyl chloride; sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; potassium carbonate; acetic acid; zinc; In methanol; ethanol; dichloromethane; acetone;
DOI:10.1016/j.ejmech.2012.04.039