(2R,3S)-3-acetoxy-6-(bis(benzyloxy)phosphoryloxy)-2-methylhexanoic acid benzyl ester

Base Information

Chemical Name:(2R,3S)-3-acetoxy-6-(bis(benzyloxy)phosphoryloxy)-2-methylhexanoic acid benzyl ester
CAS No.:541513-08-0
Molecular Formula:C₃₀H₃₅O₈P
Molecular Weight:554.577
Hs Code.:

Synonyms:(2R,3S)-3-acetoxy-6-(bis(benzyloxy)phosphoryloxy)-2-methylhexanoic acid benzyl ester

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Chemical Property of (2R,3S)-3-acetoxy-6-(bis(benzyloxy)phosphoryloxy)-2-methylhexanoic acid benzyl ester

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Technology Process of (2R,3S)-3-acetoxy-6-(bis(benzyloxy)phosphoryloxy)-2-methylhexanoic acid benzyl ester

There total 7 articles about (2R,3S)-3-acetoxy-6-(bis(benzyloxy)phosphoryloxy)-2-methylhexanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 108-24-7
acetic anhydride

: 541513-01-3
(2R,3S)-6-(bis(benzyloxy)phosphoryloxy)-3-hydroxy-2-methylhexanoic acid benzyl ester

: 541513-08-0
(2R,3S)-3-acetoxy-6-(bis(benzyloxy)phosphoryloxy)-2-methylhexanoic acid benzyl ester

Guidance literature:: With pyridine; dmap; at 20 ℃; for 18h;
DOI:10.1039/b210606j

Reference yield:

: 541515-89-3
(4R)-4-benzyl-3-[(2R,3S)-6-benzyloxy-3-hydroxy-2-methylhexanoyl]oxazolidin-2-one

: 541513-08-0
(2R,3S)-3-acetoxy-6-(bis(benzyloxy)phosphoryloxy)-2-methylhexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 97 percent / H₂ / 5percent Pd/C / methanol / 2.5 h / 1551.49 Torr

2.1: PPTS / CH₂Cl₂ / 16 h / 20 °C

3.1: n-BuLi / tetrahydrofuran / 0 °C

3.2: 1.23 g / tetrahydrofuran / 2 h / 0 °C

4.1: 200 mg / Dowex 50X₈ resin / methanol / 18 h

5.1: 247 mg / pyridine / 3 h / 0 - 20 °C

6.1: 56 percent / DMAP; pyridine / 18 h / 20 °C

With pyridine; dmap; n-butyllithium; Dowex 50X₈ resin; hydrogen; pyridinium p-toluenesulfonate; 5percent Pd/C; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/b210606j

Reference yield:

: 538-60-3
dibenzyl hydrogen phosphite

: 541513-08-0
(2R,3S)-3-acetoxy-6-(bis(benzyloxy)phosphoryloxy)-2-methylhexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: SO₂Cl₂ / CCl₄ / 1 h / 20 °C

2: 247 mg / pyridine / 3 h / 0 - 20 °C

3: 56 percent / DMAP; pyridine / 18 h / 20 °C

With pyridine; dmap; sulfuryl dichloride; In tetrachloromethane;
DOI:10.1039/b210606j