2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Base Information

Chemical Name:2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine
CAS No.:1263868-30-9
Molecular Formula:C₁₃H₉Cl₂FN₂
Molecular Weight:283.132
Hs Code.:

Synonyms:2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Suppliers and Price of 2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Chemical Property:

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Technology Process of 2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

There total 10 articles about 2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.9%

: 1263868-44-5
7-(4-fluorophenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione

: 1263868-30-9
2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Guidance literature:: With N,N-dimethyl-aniline; trichlorophosphate; at 110 ℃;

Reference yield:

: C₁₅H₁₅FN₂O₂

: 1263868-30-9
2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Guidance literature:: C₁₅H₁₅FN₂O₂; With hydrogenchloride; In water; at 60 ℃; for 16h; Inert atmosphere;

With trichlorophosphate; at 100 ℃; for 7h; Inert atmosphere;
DOI:10.1021/acs.joc.8b01734

Reference yield:

: 120-92-3
cyclopentanone

: 1263868-30-9
2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether; tetrahydrofuran / 2 h / 0 °C / Reflux

2: formic acid; dihydrogen peroxide / 20 - 50 °C

3: 3 h / 58 - 130 °C

4: ammonium hydroxide / 100 °C

5: trichlorophosphate; N,N-dimethyl-aniline / 110 °C

With ammonium hydroxide; formic acid; dihydrogen peroxide; N,N-dimethyl-aniline; trichlorophosphate; In tetrahydrofuran; diethyl ether;