Technology Process of (2R,3R)-3-(tert-butyl)-4-(2,
6-dimethoxyphenyl)-2-iso
propyl-2,3-dihydrobenzo[d
][1,3]oxaphosphole
There total 4 articles about (2R,3R)-3-(tert-butyl)-4-(2,
6-dimethoxyphenyl)-2-iso
propyl-2,3-dihydrobenzo[d
][1,3]oxaphosphole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C22H29O4P;
With
titanium(IV) isopropylate;
In
tetrahydrofuran;
for 12h;
Reflux;
With
sodium hydroxide;
In
tetrahydrofuran;
at 60 ℃;
for 0.5h;
DOI:10.1021/ja409669r
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane
2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 1 h / -78 °C
2.2: 1 h / -78 °C
3.1: titanium(IV) isopropylate / tetrahydrofuran / 12 h / Reflux
3.2: 0.5 h / 60 °C
With
titanium(IV) isopropylate; potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; n-heptane;
DOI:10.1021/ja409669r
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane
2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 1 h / -78 °C
2.2: 1 h / -78 °C
3.1: titanium(IV) isopropylate / tetrahydrofuran / 12 h / Reflux
3.2: 0.5 h / 60 °C
With
titanium(IV) isopropylate; potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; n-heptane;
DOI:10.1021/ja409669r
