(E)-N-(2-(1H-imidazol-5-yl)ethyl)-3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanamide

Base Information

Chemical Name:(E)-N-(2-(1H-imidazol-5-yl)ethyl)-3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanamide
CAS No.:218931-98-7
Molecular Formula:C₁₅H₁₆Br₂N₄O₃
Molecular Weight:460.125
Hs Code.:

Synonyms:(E)-N-(2-(1H-imidazol-5-yl)ethyl)-3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanamide

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Chemical Property of (E)-N-(2-(1H-imidazol-5-yl)ethyl)-3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanamide

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Technology Process of (E)-N-(2-(1H-imidazol-5-yl)ethyl)-3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanamide

There total 6 articles about (E)-N-(2-(1H-imidazol-5-yl)ethyl)-3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1415814-14-0
(E)-N-(2-(1H-imidazol-4-yl)ethyl)-2-(benzyloxyimino)-3-(3,5-dibromo-4-methoxyphenyl)propanamide

: 218931-98-7
(E)-N-(2-(1H-imidazol-5-yl)ethyl)-3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanamide

Guidance literature:: With hydrogen; palladium; In 1,4-dioxane; acetic acid; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ol303057a

Reference yield: 78.0%

: 1248588-79-5
(E)-N-(2-(1H-imidazol-5-yl)ethyl)-3-(3,5-dibromo-4-methoxyphenyl)-2-(4-methoxybenzyloxyimino)propanamide

: 218931-98-7
(E)-N-(2-(1H-imidazol-5-yl)ethyl)-3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanamide

Guidance literature:: With aluminum (III) chloride; methoxybenzene; In dichloromethane; at 20 ℃; for 0.0833333h;
DOI:10.1016/j.tetlet.2010.07.016

Reference yield:

: 108940-96-1
3,5-dibromo-4-methoxybenzaldehyde

: 218931-98-7
(E)-N-(2-(1H-imidazol-5-yl)ethyl)-3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium acetate / acetic acid / 110 - 120 °C / Inert atmosphere

2: sodium hydroxide / water / 80 - 90 °C / Inert atmosphere

3: sodium ethanolate / ethanol / 70 °C / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 20 °C / Inert atmosphere

5: palladium; hydrogen / acetic acid; 1,4-dioxane / 6 h / 20 °C / Inert atmosphere

With hydrogen; sodium ethanolate; sodium acetate; benzotriazol-1-ol; palladium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; acetic acid;
DOI:10.1021/ol303057a