(2S)-N-[4-{1-(3-propoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-nitro-benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

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Chemical Name:(2S)-N-[4-{1-(3-propoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-nitro-benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal
CAS No.:1372097-25-0
Molecular Formula:C₂₈H₃₇N₅O₆S₂
Molecular Weight:603.764
Hs Code.:

Synonyms:(2S)-N-[4-{1-(3-propoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-nitro-benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

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Chemical Property of (2S)-N-[4-{1-(3-propoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-nitro-benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

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Technology Process of (2S)-N-[4-{1-(3-propoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-nitro-benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

There total 4 articles about (2S)-N-[4-{1-(3-propoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-nitro-benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 52210-90-9
1-(pyridin-4-yl)-2-imidazolidinone

: 343308-55-4
(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

: 1372097-25-0
(2S)-N-[4-{1-(3-propoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-nitro-benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: 1-(pyridin-4-yl)-2-imidazolidinone; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h;
DOI:10.2174/157018012799129927

Reference yield:

: 140647-02-5
(2S)-N-(4-hydroxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

: 1372097-25-0
(2S)-N-[4-{1-(3-propoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-nitro-benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 48 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

2.2: 4 h / 0 - 20 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; acetone;
DOI:10.2174/157018012799129927

Reference yield:

: 504-24-5
4-aminopyridine

: 1372097-25-0
(2S)-N-[4-{1-(3-propoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-nitro-benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 5.5 h / 20 °C / Cooling with ice

2.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 4 h / 0 - 20 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.2174/157018012799129927