(R)-4-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-pentanoic acid benzhydryl ester

Base Information

Chemical Name:(R)-4-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-pentanoic acid benzhydryl ester
CAS No.:161683-27-8
Molecular Formula:C₂₉H₃₉NO₅Si
Molecular Weight:509.718
Hs Code.:

Synonyms:(R)-4-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-pentanoic acid benzhydryl ester

Suppliers and Price of (R)-4-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-pentanoic acid benzhydryl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-4-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-pentanoic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-4-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-pentanoic acid benzhydryl ester

There total 5 articles about (R)-4-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-pentanoic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: (R)-4-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-hydroxy-pentanoic acid benzhydryl ester

: 161683-27-8
(R)-4-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-pentanoic acid benzhydryl ester

Guidance literature:: With pyridine; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In toluene; for 3.5h; Ambient temperature; other reagents: pyridinium chlorochromate; sodium dichromate; 1.) dimethyl sulfoxide, trifluoroacetic anhydride, 2.) triethylamine or triethylamine/trimethylsilyl chloride;
DOI:10.1016/S0040-4020(96)01093-9

Reference yield:

: 91-01-0
1,1-Diphenylmethanol

: 161683-27-8
(R)-4-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-pentanoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂

2: 89 percent / zinc, cupric bromide / tetrahydrofuran / 1.5 h / 25 - 30 °C

3: 87 percent / dicyclohexylcarbodiimide, pyridine, trifluoroacetic acid, dimethyl sulfoxide / toluene / 3.5 h / Ambient temperature; other reagents: pyridinium chlorochromate; sodium dichromate; 1.) dimethyl sulfoxide, trifluoroacetic anhydride, 2.) triethylamine or triethylamine/trimethylsilyl chloride

With pyridine; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; copper(ll) bromide; zinc; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/S0040-4020(96)01093-9

Reference yield:

: 96613-71-7
4(R)-<1-buten-3(S)-yl>-3(S)-<1(R)-<(tert-butyldimethylsilyl)oxy>ethyl>-2-oxoazetidine

: 161683-27-8
(R)-4-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-pentanoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) ozone, 2.) dimethyl sulfide / 1.) CH₂Cl₂, methanol, -78 deg C, 1 h, 2.) CH₂Cl₂, methanol, -78 deg C -> room temperature

2: 89 percent / zinc, cupric bromide / tetrahydrofuran / 1.5 h / 25 - 30 °C

3: 87 percent / dicyclohexylcarbodiimide, pyridine, trifluoroacetic acid, dimethyl sulfoxide / toluene / 3.5 h / Ambient temperature; other reagents: pyridinium chlorochromate; sodium dichromate; 1.) dimethyl sulfoxide, trifluoroacetic anhydride, 2.) triethylamine or triethylamine/trimethylsilyl chloride

With pyridine; dimethylsulfide; ozone; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; copper(ll) bromide; zinc; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(96)01093-9