(2R,3R,4S)-2-(4-Aminomethyl-benzylamino)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid ethyl ester

Base Information

Chemical Name:(2R,3R,4S)-2-(4-Aminomethyl-benzylamino)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid ethyl ester
CAS No.:176388-99-1
Molecular Formula:C₂₆H₃₇N₃O₅
Molecular Weight:471.597
Hs Code.:

Synonyms:(2R,3R,4S)-2-(4-Aminomethyl-benzylamino)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid ethyl ester

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Chemical Property of (2R,3R,4S)-2-(4-Aminomethyl-benzylamino)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid ethyl ester

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Technology Process of (2R,3R,4S)-2-(4-Aminomethyl-benzylamino)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid ethyl ester

There total 1 articles about (2R,3R,4S)-2-(4-Aminomethyl-benzylamino)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 539-48-0
p-xylylidenediamine

: (2S/R,3R/S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2,3-epoxy-5-phenylpentanoic acid ethyl ester

: 176388-99-1
(2R,3R,4S)-2-(4-Aminomethyl-benzylamino)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid ethyl ester

Guidance literature:: In ethanol; at 80 ℃; for 20h;
DOI:10.1021/jm9508696

Reference yield: 76.0%

: 23249-97-0
4-(2'-benzimidazolyl)propionic acid

: 176388-99-1
(2R,3R,4S)-2-(4-Aminomethyl-benzylamino)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid ethyl ester

: 176389-00-7
(2R,3R,4S)-2-{4-[(3-1H-Benzoimidazol-2-yl-propionylamino)-methyl]-benzylamino}-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide; for 72h; Ambient temperature;
DOI:10.1021/jm9508696

Reference yield:

: 176388-99-1
(2R,3R,4S)-2-(4-Aminomethyl-benzylamino)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid ethyl ester

: SDZ 283407

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / 1-hydroxybenzotriazole, N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide; dioxane / 72 h / Ambient temperature

2: 3N HCl / CH₂Cl₂; methanol; diethyl ether / 3 h / Ambient temperature

3: 1-hydroxybenzotriazole, N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 72 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9508696