methanesulfonic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4,5-dihydroxy-pentyl ester

Base Information

• Chemical Name: methanesulfonic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4,5-dihydroxy-pentyl ester
• CAS No.: 919608-30-3
• Molecular Formula: C₂₅H₃₈O₆SSi
• Molecular Weight: 494.725
• Mol file: 919608-30-3.mol

Synonyms:methanesulfonic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4,5-dihydroxy-pentyl ester

Chemical Property of methanesulfonic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4,5-dihydroxy-pentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methanesulfonic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4,5-dihydroxy-pentyl ester

There total 5 articles about methanesulfonic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4,5-dihydroxy-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methanesulfonic acid 3-(tert-butyl-diphenyl-silanyloxy)-1-[2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-2-methyl-propyl ester (919608-29-0) → methanesulfonic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4,5-dihydroxy-pentyl ester (919608-30-3)

Guidance literature:

With camphor-10-sulfonic acid; In methanol; at 20 ℃; for 2h;

DOI:10.1002/anie.200602860

Reference yield:

5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-pentane-1,3-diol (919608-47-2) → methanesulfonic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4,5-dihydroxy-pentyl ester (919608-30-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 3.59 g / imidazole / CH₂Cl₂ / 1 h / 20 °C

2: 98 percent / TEA / CH₂Cl₂ / 0 - 20 °C

3: 84 percent / CSA; methanol / 2 h / 20 °C

With 1H-imidazole; methanol; TEA; camphor-10-sulfonic acid; In dichloromethane;

DOI:10.1016/j.tet.2007.07.005

Reference yield:

3-[5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-2-methyl-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one (919608-28-9) → methanesulfonic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4,5-dihydroxy-pentyl ester (919608-30-3)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium borohydride / diethyl ether; tetrahydrofuran / 0 - 20 °C

2: 3.59 g / imidazole / CH₂Cl₂ / 1 h / 20 °C

3: 98 percent / TEA / CH₂Cl₂ / 0 - 20 °C

4: 84 percent / CSA; methanol / 2 h / 20 °C

With 1H-imidazole; methanol; lithium borohydride; TEA; camphor-10-sulfonic acid; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/j.tet.2007.07.005

upstream raw materials:

methanesulfonic acid 3-(tert-butyl-diphenyl-silanyloxy)-1-[2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-2-methyl-propyl ester

5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-pentane-1,3-diol

3-[5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-2-methyl-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

1-(tert-butyl-diphenyl-silanyloxy)-5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-pentan-3-ol

Downstream raw materials:

C₃₂H₄₄O₈S₂Si

C₂₄H₃₆O₄

C₂₅H₃₄O₂Si

C₂₉H₄₀O₅S