(R)-2-[4-chloro-N-(3-cyanopropyl)phenylsulfonamido]-5,5,5-tri-fluoropentanamide

Base Information

Chemical Name:(R)-2-[4-chloro-N-(3-cyanopropyl)phenylsulfonamido]-5,5,5-tri-fluoropentanamide
CAS No.:1370705-43-3
Molecular Formula:C₁₅H₁₇ClF₃N₃O₃S
Molecular Weight:411.832
Hs Code.:

Synonyms:(R)-2-[4-chloro-N-(3-cyanopropyl)phenylsulfonamido]-5,5,5-tri-fluoropentanamide

Suppliers and Price of (R)-2-[4-chloro-N-(3-cyanopropyl)phenylsulfonamido]-5,5,5-tri-fluoropentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-[4-chloro-N-(3-cyanopropyl)phenylsulfonamido]-5,5,5-tri-fluoropentanamide

Chemical Property:

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Technology Process of (R)-2-[4-chloro-N-(3-cyanopropyl)phenylsulfonamido]-5,5,5-tri-fluoropentanamide

There total 1 articles about (R)-2-[4-chloro-N-(3-cyanopropyl)phenylsulfonamido]-5,5,5-tri-fluoropentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1146699-67-3
(R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide

: 5332-06-9
4-bromobutanenitrile

: 1370705-43-3
(R)-2-[4-chloro-N-(3-cyanopropyl)phenylsulfonamido]-5,5,5-tri-fluoropentanamide

Guidance literature:: With tetra-(n-butyl)ammonium iodide; caesium carbonate; In N,N-dimethyl-formamide; at 23 ℃; for 12h;
DOI:10.1021/jm300094u

Reference yield:

: 1370705-43-3
(R)-2-[4-chloro-N-(3-cyanopropyl)phenylsulfonamido]-5,5,5-tri-fluoropentanamide

: C₁₅H₂₀ClF₃N₄O₄S

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In ethanol; water; at 23 - 80 ℃; for 16h;
DOI:10.1021/jm300094u

Reference yield:

: 1370705-43-3
(R)-2-[4-chloro-N-(3-cyanopropyl)phenylsulfonamido]-5,5,5-tri-fluoropentanamide

: 1370705-49-9
C₁₆H₁₈ClF₃N₄O₄S

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; triethylamine / ethanol; water / 16 h / 23 - 80 °C

2: boron trifluoride diethyl etherate / 1,2-dichloro-ethane / 16 h / 80 °C

With boron trifluoride diethyl etherate; hydroxylamine hydrochloride; triethylamine; In ethanol; water; 1,2-dichloro-ethane;
DOI:10.1021/jm300094u