1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-1-(cyclopropylsulfonyl)-4-(4-fluorophenyl)pyrrolidin-3-yl]-1,3-dimethylurea

Base Information

Chemical Name:1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-1-(cyclopropylsulfonyl)-4-(4-fluorophenyl)pyrrolidin-3-yl]-1,3-dimethylurea
CAS No.:1218763-31-5
Molecular Formula:C₂₄H₂₄F₇N₃O₃S
Molecular Weight:567.528
Hs Code.:

Synonyms:1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-1-(cyclopropylsulfonyl)-4-(4-fluorophenyl)pyrrolidin-3-yl]-1,3-dimethylurea

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Chemical Property of 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-1-(cyclopropylsulfonyl)-4-(4-fluorophenyl)pyrrolidin-3-yl]-1,3-dimethylurea

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Technology Process of 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-1-(cyclopropylsulfonyl)-4-(4-fluorophenyl)pyrrolidin-3-yl]-1,3-dimethylurea

There total 2 articles about 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-1-(cyclopropylsulfonyl)-4-(4-fluorophenyl)pyrrolidin-3-yl]-1,3-dimethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1218761-04-6
1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)pyrrolidin-3-yl]-1,3-dimethylurea monohydrochloride

: 139631-62-2
cyclopropanesulfonyl chloride

: 1218763-31-5
1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-1-(cyclopropylsulfonyl)-4-(4-fluorophenyl)pyrrolidin-3-yl]-1,3-dimethylurea

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 10 - 35 ℃; for 5h;

Reference yield:

: 1218761-03-5
tert-butyl (3S,4R)-3-[{[3,5-bis(trifluoromethyl)phenyl](methyl)carbamoyl}(methyl)amino]-4-(4-fluorophenyl)pyrrolidine-1-carboxylate

: 1218763-31-5
1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-1-(cyclopropylsulfonyl)-4-(4-fluorophenyl)pyrrolidin-3-yl]-1,3-dimethylurea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / isopropyl alcohol / 2.5 h / 10 - 45 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 10 - 35 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; isopropyl alcohol;