2-(2-hydroxymethyl-4-dimethylamino-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridine-7-ol

Base Information

Chemical Name:2-(2-hydroxymethyl-4-dimethylamino-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridine-7-ol
CAS No.:1189165-85-2
Molecular Formula:C₁₅H₁₉N₃O₂S
Molecular Weight:305.401
Hs Code.:

Synonyms:2-(2-hydroxymethyl-4-dimethylamino-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridine-7-ol

Suppliers and Price of 2-(2-hydroxymethyl-4-dimethylamino-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridine-7-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-hydroxymethyl-4-dimethylamino-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridine-7-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(2-hydroxymethyl-4-dimethylamino-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridine-7-ol

There total 7 articles about 2-(2-hydroxymethyl-4-dimethylamino-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridine-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189166-13-9
C₂₀H₂₇N₃O₄S

: 1189165-85-2
2-(2-hydroxymethyl-4-dimethylamino-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridine-7-ol

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2010.05.021

Reference yield:

: 1189166-11-7
methyl 2-(aminocarbonothioyl)-5-(dimethylamino)benzoate

: 1189165-85-2
2-(2-hydroxymethyl-4-dimethylamino-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridine-7-ol

Guidance literature:: Multi-step reaction with 3 steps

1: methanol

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 1189166-02-6
5-hydroxy-7-oxa-3-aza-bicyclo[4.1.0]heptane-3-carboxylic acid tert-butyl ester

: 1189165-85-2
2-(2-hydroxymethyl-4-dimethylamino-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridine-7-ol

Guidance literature:: Multi-step reaction with 4 steps

1: Dess-Martin periodane / dichloromethane / 20 °C

2: methanol

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

4: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; Dess-Martin periodane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;