4-(4-((R)-(tert-butyldimethylsilyloxy)(4'-chlorobiphenyl-2-yl)methyl)piperidin-1-yl)-N-(4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide

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Chemical Name:4-(4-((R)-(tert-butyldimethylsilyloxy)(4'-chlorobiphenyl-2-yl)methyl)piperidin-1-yl)-N-(4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide
CAS No.:1357575-90-6
Molecular Formula:C₅₇H₇₃ClF₃N₅O₇S₃Si
Molecular Weight:1156.97
Hs Code.:

4-(4-((R)-(tert-butyldimethylsilyloxy)(4'-chlorobiphenyl-2-yl)methyl)piperidin-1-yl)-N-(4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide

Synonyms:4-(4-((R)-(tert-butyldimethylsilyloxy)(4'-chlorobiphenyl-2-yl)methyl)piperidin-1-yl)-N-(4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide

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Chemical Property of 4-(4-((R)-(tert-butyldimethylsilyloxy)(4'-chlorobiphenyl-2-yl)methyl)piperidin-1-yl)-N-(4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide

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Technology Process of 4-(4-((R)-(tert-butyldimethylsilyloxy)(4'-chlorobiphenyl-2-yl)methyl)piperidin-1-yl)-N-(4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide

There total 20 articles about 4-(4-((R)-(tert-butyldimethylsilyloxy)(4'-chlorobiphenyl-2-yl)methyl)piperidin-1-yl)-N-(4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.5%

: 1357575-15-5
(R)-4-(4-((tert-butyldimethylsilyloxy)(4'-chlorobiphenyl-2-yl)methyl)piperidin-1-yl)benzoic acid

: 1357575-89-3
4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

: 1357575-90-6
4-(4-((R)-(tert-butyldimethylsilyloxy)(4'-chlorobiphenyl-2-yl)methyl)piperidin-1-yl)-N-(4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 18 - 25 ℃;

Reference yield:

: 1187929-79-8
(3S)-3-aminomethyl-4-{[(tert-butyl)oxy]carbonyl}morpholine

: 1357575-90-6
4-(4-((R)-(tert-butyldimethylsilyloxy)(4'-chlorobiphenyl-2-yl)methyl)piperidin-1-yl)-N-(4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / dichloromethane / 0.5 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h

3.1: diphenylsilane / carbonylhydridetris(triphenylphosphine)rhodium(I) / tetrahydrofuran / 0.5 h

4.1: hydrogenchloride; water

5.1: N-ethyl-N,N-diisopropylamine; HATU / ISOPROPYLAMIDE / 1 h / 18 - 25 °C

6.1: borane-THF / tetrahydrofuran / 16 h / 18 - 25 °C

6.2: 3 h / 80 °C

6.3: 18 - 25 °C / pH 10

7.1: dmap; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 - 25 °C

With pyridine; hydrogenchloride; dmap; borane-THF; diphenylsilane; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; carbonylhydridetris(triphenylphosphine)rhodium(I); In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1357575-86-0
(S)-tert-butyl 3-((N-ethylacetamido)methyl)morpholine-4-carboxylate

: 1357575-90-6
4-(4-((R)-(tert-butyldimethylsilyloxy)(4'-chlorobiphenyl-2-yl)methyl)piperidin-1-yl)-N-(4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: diphenylsilane / carbonylhydridetris(triphenylphosphine)rhodium(I) / tetrahydrofuran / 0.5 h

2.1: hydrogenchloride; water

3.1: N-ethyl-N,N-diisopropylamine; HATU / ISOPROPYLAMIDE / 1 h / 18 - 25 °C

4.1: borane-THF / tetrahydrofuran / 16 h / 18 - 25 °C

4.2: 3 h / 80 °C

4.3: 18 - 25 °C / pH 10

5.1: dmap; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 - 25 °C

With hydrogenchloride; dmap; borane-THF; diphenylsilane; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; carbonylhydridetris(triphenylphosphine)rhodium(I); In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE;